search

Active clinical trials for "Fibrosis"

Results 301-310 of 3184

Evaluation of the Value of 18F-Fluoromisonidazole (18F-FMISO) Positron Emission Tomography Hypoxia...

Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, lethal disease of unknown etiology and with a variable course. There is currently no test in routine care that can assess both the anatomical and functional damage of the disease at an early stage. This is the first human study in IPF to evaluate the value of a non-invasive tracer, 18F-fluoromisonidazole (18F-FMISO), targeting hypoxia in IPF patients. This is a Phase I, proof-of-concept, single-center, open-label, parallel group study. It will include 2 groups: 1 group of 10 IPF patients 1 group of 10 healthy volunteers matched to IPF patients for age and gender

Recruiting32 enrollment criteria

FEED-Cystic Fibrosis (FEED-CF)

Cystic FibrosisCystic Fibrosis-related Diabetes

The goal of this study is to determine the extent to which excess dietary sugars serve as a precipitating factor in glucose intolerance in adults with cystic fibrosis (CF), a population at especially high risk for a unique form of diabetes (CF-related diabetes, CFRD) and with standard-of-care dietary recommendations (high-calorie, high-fat) that conflict with recommendations for other forms of diabetes. This trial will investigate if the typical high-sugar, high-fat CF diet plays a role in diabetes risk and visceral fat accumulation in people with CF. A total of 30 participants will get a low-added sugar, high-fat diet and the other 30 will get a standard CF diet with no sugar restrictions. Participants will be randomized to the diet group they are assigned. All foods will be provided for 8 weeks.

Recruiting19 enrollment criteria

99mTc-HFAPI SPECT/CT in Pulmonary Fibrosis

Pulmonary Fibrosis

This prospective study will investigate the potential usefulness of 99mTc labeled FAPI SPECT/CT in the diagnosis, treatment response assessment, and follow-up of pulmonary fibrosis.

Recruiting6 enrollment criteria

Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients

Non-alcoholic Fatty Liver Disease (NAFLD)Alcoholic Liver Disease (ALD)1 more

The primary objective of the SOPRANO study is to compare two blood fibrosis tests, the eLIFT and the FibroMeter, for the screening of advanced liver fibrosis in patients with NAFLD and/or ALD from primary care centers.

Recruiting17 enrollment criteria

Multimodality Biomarkers for Noninvasive Assessment of the Fontan Patient

Single-ventricleMyocardial Fibrosis

This is a single center prospective longitudinal exercise training study and will enroll approximately 50 Fontan patients and 20 controls of a similar age, gender, BMI and physical activity level between the ages of 10-40 years. Participants will undergo an MRI of the Fontan circulation. This will include imaging of the heart, lung and liver. This will include specific imaging for tissue characterization and assessment of myocardial fibrosis, liver fibrosis and disproportionate pulmonary blood flow. The investigators will then draw blood (approximately 10 ml) for assessment of serum biomarkers and circulating microRNAs of interest. The participants will undergo exercise testing and will then start a 3-6 month long cardiac rehabilitation program. After the 3-6 month study period the participants will return back for a follow up and repeat all the testing completed at enrollement.

Active9 enrollment criteria

Patienthèque of Finisterian (South of Brittany) Children With Cystic Fibrosis in the Time of Precision...

Cystic Fibrosis

The objective of this study is to evaluate the relevance of Porphyromonas as a biomarker predicting the risk of P. aeruginosa primocolonization in children form 0 to 18 years old with cystic fibrosis.

Recruiting10 enrollment criteria

Molecular Imaging Probes to Inform Heterogeneity in Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

The purpose of the study is to see if imaging with fluorine-18 Fluorodeoxyglucose ([18F] FDG) and fluorine-18 Displacement Per Atom ([18F]DPA-714) using positron emission tomography and computed tomography (PET/CT) will show lung inflammation and fibrosis in patients diagnosed with idiopathic pulmonary fibrosis (IPF). This study may help physicians and researchers better understand how best to treat patients with IPF in the future.

Recruiting16 enrollment criteria

Markers of Osteoporosis in Cystic Fibrosis

Cystic Fibrosis

Main Study Up to 100 subjects, both non-CF volunteers and Cystic Fibrosis (CF) patients, will participate in a single study visit that will include a DEXA scan, micro CT, and blood collection. Denosumab (Prolia) Sub study Approximately 10 adult subjects with CF who participated in the main study and have results indicating bone disease will receive treatment with Denosumab for up to 5 years. They will be asked to return annually for repeat DEXA scans, micro CT, and blood collection.

Recruiting9 enrollment criteria

Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis...

Cystic FibrosisLung Transplant; Complications

Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis

Recruiting6 enrollment criteria

Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID...

Pulmonary FibrosisCOVID-19 Pneumonia1 more

The primary purpose of this study is to determine whether the drug sirolimus reduces the likelihood of developing of pulmonary fibrosis in patients who are hospitalized with COVID-19 pneumonia.

Recruiting31 enrollment criteria
1...303132...319

Need Help? Contact our team!


We'll reach out to this number within 24 hrs