Active clinical trials for "Cocaine-Related Disorders"

The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the treatment of cocaine dependence using reserpine, gabapentin, or lamotrigine vs. an unmatched placebo control.

The purpose of this study is to evaluate the effects of pergolide on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate dependent cocaine users.

The purpose of this study is to compare the efficacy of benztropine (or DA reuptake inhibitor) with atropine and placebo in affecting stimulated craving to cocaine cues.

The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.

The purpose of this study is to determine the effects of phenytoin on the self-administration of smoked cocaine.

The purpose of this study is to determine the HPA axis and adrenergic system activation in response to cocaine administration.

The purpose of this study is to determine the effect of labetalol treatment on the subjective and physiological effects of cocaine.

The purpose of this study is to develop an experimental paradigm to examine acute withdrawal symptoms from cocaine.

The purpose of this study is to develop models for early Phase II testing of potential medications for cocaine dependence: amoxapine, risperidone and other agents. The study was a controlled pilot trial of risperidone in opiate-dependent patients on methadone maintenance. The study explored whether risperidone reduced cocaine use, cocaine craving, and cocaine subjective effects in patients on methadone maintenance who abused cocaine and whether it had an acceptable side effect profile. This

The objective of this research is to identify the functional neural mechanisms (as assessed using fMRI) of short-term N-acetylcysteine (NAC) administration among methadone-maintained individuals with cocaine dependence.