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Active clinical trials for "Colorectal Neoplasms"

Results 131-140 of 4253

Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors

MelanomaHepatocellular Carcinoma (HCC)4 more

The purpose of this study is to characterize the safety, tolerability, PK, and efficacy of INCB 99280 in combination with ipilimumab in participants with select solid tumors.

Recruiting31 enrollment criteria

A First-In-Human Trial of pTTL in Advanced Colorectal Cancer

Colorectal Cancer

This is an open-label, non-randomised FIH trial investigating the safety and tolerability of a novel ATMP, pTTL, composed of autologous tumour-draining lymph node-derived T cells stimulated in vitro with personalised cancer neoantigens. The neoantigens are selected through a process starting with next generation sequencing (NGS) of tumour material from the patient followed by selection of neoantigenic mutations using an in-house software, PIOR®. Selected neoantigen epitopes are expressed as recombinant proteins, NAG, and used to stimulate T cells to promote neoantigen-specific T cell expansion in vitro in pTTL production. pTTL is thus based on autologous cells stimulated with patient-specific neoantigens. In consequence, every pTTL product is unique and designated for use in one single individual. pTTL will be administered to patients with stage IV colorectal cancer (CRC) as a single intravenous dose.

Recruiting47 enrollment criteria

Robotic vs Laparoscopic D3-D4 Lymphadenectomy for Colorectal Cancer

Colorectal Cancer

Approximately one third of patients with colorectal cancer are diagnosed as locally advanced stage with metastasis to N3 - N4 lymph nodes requiring a D3 - D4 lymphadenectomy. Our previous study has indicated that, by laparoscopic approach, the extended abdomino-iliac lymphadenectomy, the so-called D3-D4 lymph node dissection, could be performed with quick convalescence and similar oncologic efficacy for the treatment of advanced recto-sigmoid cancer with metastatic lesions over N3-N4 lymph nodes, as compared with traditional open surgery. In the present study, the investigators will further compare the oncologic and functional outcomes of robotic versus laparoscopic approach in performing such challenging surgical procedures for patients with advanced colorectal cancer requiring a D3-D4 lymphadenectomy through a randomized prospective clinical trial.

Recruiting12 enrollment criteria

A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard...

Solid TumorBreast Cancer3 more

This proposed Phase I clinical trial of SON-DP is an FIH, open-label, Phase Ia/Ib dose escalation and expansion study to evaluate the safety, tolerability, PK, and PD of SON-DP in participants with relapsed/refractory/intolerant to standard of care therapies, for advanced/ metastatic solid tumors.

Recruiting19 enrollment criteria

Evaluation of SNDX-5613 in Participants With Colorectal Cancer and Other Solid Tumors

Colorectal CancerSolid Tumors

This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of SNDX-5613 in participants with colorectal cancer (CRC) or other solid tumors who have failed at least 1 prior line of therapy.

Recruiting26 enrollment criteria

Clinical Study on the Efficacy of Autologous Cell Factor Induced Killer Cells in the Treatment of...

Colorectal Cancer

This project plans to use CIK combined with chemotherapy, immunotherapy and targeted therapy to treat CRC patients, so as to explore the effectiveness of CIK treatment and the CRC subtypes more suitable for CIK treatment, thereby improving the survival rate and quality of life of CRC patients.

Recruiting10 enrollment criteria

Precision Chemotherapy Based on Organoid Drug Sensitivity for Colorectal Cancer

Colorectal Cancer

The purpose of this study is to investigate whether chemotherapy guided by patient-derived tumor organoid drug test can improve the outcomes of stage IV colorectal cancer.

Recruiting9 enrollment criteria

Efficacy and Safety of Triweekly Cetuximab in Combination With Capecitabine as First-line Maintenance...

Metastatic Colorectal Cancer

To explore the safety, efficacy and pharmacokinetic (PK) characteristics of triweekly cetuximab in combination with capecitabine as first-line maintenance treatment for KRAS/BRAF wild-type metastatic colorectal cancer: a single-arm, a single-center, Phase 1b trial. Meanwhile, Exploring the maximum tolerant dose or recommended II research dose of triweekly cetuximab combined with a fixed dose of capecitabine using '3+3' dose climbing Phase I experiment.

Recruiting28 enrollment criteria

Underwater Versus Conventional Endoscopic Mucosal Resection in the Treatment of Non-pedunculated...

Colorectal PolypColorectal Neoplasms

A prospective, randomized, controlled study to compare the efficacy and safety of underwater endoscopic mucosal resection and conventional endoscopic mucosal resection in removal of non-pedunculated colorectal polyps

Recruiting9 enrollment criteria

Cadonilimab in Locally Advanced MSI-H/dMMR Colorectal Cancer

dMMR Colorectal Cancer

This is a two-arm phase II clinical study to evaluate the efficacy and safety of Cadonilimab (a PD-1/CTLA-4 bispecific antibody) in MSI-H/dMMR locally advanced colorectal cancer as the regimen of neoadjuvant treatment. Eligible patients will receive Cadonilimab monotherapy for eight cycles before surgery and part of patients may exempt from surgery.

Recruiting20 enrollment criteria
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