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Active clinical trials for "Seizures"

Results 41-50 of 775

Seizure Treatment in Glioma

Glioma

Currently, treatment with a specific anti-epileptic drug mainly depends on the physicians' preference, as there are no studies supporting the use of one specific anticonvulsant in glioma patients. The overall aim of this randomized controlled trial is to directly compare the effectiveness of treatment with levetiracetam or valproic acid in glioma patients with a first seizure.

Recruiting9 enrollment criteria

Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients

Seizures

In this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status epilepticus. The course of treatment will consist of an initial 10 minute PLIFU treatment session with an option for a 2nd session if necessary. The primary objective of this study is to determine whether PLIFU reduces or suppresses epileptic activity in patients with Non-Convulsive Status Epilepticus (NCSE)/Focal Motor Status Epilepticus (FMSE) that have not responded to standard of care.

Recruiting10 enrollment criteria

A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years...

Stereotypical Prolonged Seizures

The purpose of the study is to evaluate the long-term safety and tolerability of Staccato alprazolam.

Enrolling by invitation20 enrollment criteria

Cenobamate Open-Label Extension Study for YKP3089C025

Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy

52 Week Open-Label Safety Study of Cenobamate for Subjects who Complete YKP3089C025 (core study)

Enrolling by invitation4 enrollment criteria

Thermocoagulation in Drug Resistant Focal Epilepsy

EpilepsySeizures4 more

Therapeutic thermocoagulation will be carried out in patients with drug-resistant focal epilepsy in cases where an epileptogenic zone is found and proven according to stereo-electroencephalography (SEEG) data.

Enrolling by invitation18 enrollment criteria

A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects...

Partial Seizures With or Without Secondary GeneralizationEpilepsy

The purpose of the study is to evaluate the long-term safety and tolerability of Brivaracetam (BRV) in focal epilepsy subjects with partial seizures and to evaluate the maintenance of efficacy of BRV over time.

Enrolling by invitation11 enrollment criteria

The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients...

Epileptic Seizures Related to Drugs

Exploring the efficacy and safety of oral minocycline combined with antiepileptic drugs in the treatment of drug-resistant epilepsy in NORSE patients, obtaining preliminary research data, and providing evidence and data support for the next large-scale randomized controlled clinical study.

Enrolling by invitation17 enrollment criteria

Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure...

Focal Onset SeizureFocal Onset Epilepsy

This Phase 2, prospective, interventional, active extension study was designed to evaluate the long-term safety and tolerability of NBI-921352 as adjunctive therapy in adult participants with focal onset seizures who completed 11 weeks of treatment in randomized, double-blind, placebo-controlled Study NBI-921352-FOS2021. Eligible participants may enroll directly following the completion of the Week 11 study visit of Study NBI-921352-FOS2021 or after a gap following completion of that study.

Enrolling by invitation6 enrollment criteria

An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures...

Seizures

The purpose of this study is to assess the long-term safety and tolerability of CVL-865 as adjunctive therapy in participants with focal onset seizures.

Enrolling by invitation13 enrollment criteria

Acoustic Stimulation for Seizure Suppression

Epilepsy

The objective of this study is to test the feasibility and physiological effect of low-frequency (1 Hz) acoustic stimulation delivered during nocturnal NREM sleep in epilepsy patients. The long-term goal is to develop this protocol for daily, long-term use in a home setting, for nocturnal seizure and IED suppression

Enrolling by invitation17 enrollment criteria
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