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Active clinical trials for "Constipation"

Results 291-300 of 861

Proof-of-Principle Study of TC-6499 in the Treatment of Constipation Predominant Irritable Bowel...

Irritable Bowel Syndrome

Study is to assess the effectiveness of TC-6499 in the treatment of constipation predominant IBS patients over a 28-day period.

Completed3 enrollment criteria

Efficacy and Safety Study of Prucalopride to Treat Chronic Constipation

Constipation

The purpose of this study is to determine whether prucalopride is safe and effective in the treatment of chronic constipation. Hypothesis: Prucalopride 2 mg and 4 mg given once daily for 12 weeks is superior to placebo for the treatment of patients with chronic constipation and is well tolerated in those patients

Completed15 enrollment criteria

Efficacy and Safety Study of Prucalopride for the Treatment of Patients With Chronic Constipation...

Constipation

The purpose of this study is to determine whether prucalopride is safe and effective in the treatment of chronic constipation Hypothesis: Prucalopride 2 mg and 4 mg given once daily for 12 weeks is superior to placebo for the treatment of patients with chronic constipation and is well tolerated in those patients

Completed15 enrollment criteria

Physiotherapeutic Intervention in Children With Chronic Functional Constipation

Chronic Constipation

The purpose of this study is to determine whether physiotherapy is effective in the treatment of the chronic functional constipation in children.

Completed7 enrollment criteria

Thorough Corrected QT Interval (QTc) Study To Evaluate Possible Effects of Prucalopride on ECG Parameters...

Constipation

This is a 2-arm, parallel-group active- and placebo-controlled, double-blind randomised study, stratified by gender and with a hybrid crossover group design, to compare treatment with prucalopride 2 mg/day (intended therapeutic dose) and prucalopride 10 mg/day (supratherapeutic dose) with placebo. A single oral dose of 400 mg moxifloxacin is included as a positive control in terms of the effect on cardiac repolarisation. Study hypothesis: Treatment with therapeutic (2 mg) or supratherapeutic (10 mg) doses of prucalopride in healthy male and female volunteers will not increase QTc interval compared to placebo.

Completed19 enrollment criteria

Glucomannan for Childhood Functional Constipation.

Functional Constipation

The purpose of this study is to determine whether administration of glucomannan (dietary fiber) is effective in treating functional constipation in children.

Completed8 enrollment criteria

Evaluation of Prucalopride in Male Subjects With Chronic Constipation.

Male Subjects With Chronic Constipation

This is a multi-centre, randomised, parallel-group, double-blind, placebo-controlled phase III trial to evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation. Furthermore the safety, tolerability, effect on quality of life and effect on symptoms of prucalopride will be assessed.

Completed29 enrollment criteria

SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation

Chronic Idiopathic Constipation

This is a Phase 2a, randomized, double-blind, placebo-controlled, 14-day repeat oral, dose ranging study to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) effects of SP-304 in patients with chronic idiopathic constipation.

Completed7 enrollment criteria

Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable...

Constipation-predominant Irritable Bowel Syndrome

In this study the investigators aim to compare the efficacy of neomycin to a combination of rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test. This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.

Completed16 enrollment criteria

Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation

Constipation

The main purpose of this study is to evaluate the tolerance of long term repeated doses of Forlax® 10g versus lactulose in elderly ambulatory or institutionalized patients, paying special attention to digestive and nutritional status.

Completed9 enrollment criteria
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