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Active clinical trials for "Corneal Diseases"

Results 21-30 of 90

Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye

Fuch's DystrophyCorneal Disorders1 more

The purpose of this research is to evaluate the optical coherence tomography (OCT), to image diseases of the eye. OCT may be useful for the early diagnosis and monitoring of a variety of diseases involving the eye, such as Fuch's Dystrophy (type of eye disease) and retinal damage (eye diseases in the back of the eye) due to diabetes.

Active8 enrollment criteria

Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia...

KeratoconusCorneal Ectasia

The objectives of this study are to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System in impeding the progression of, and/or reducing maximum corneal curvature.

Terminated39 enrollment criteria

First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of...

Corneal DiseaseCorneal Opacity1 more

Prospective, open label, single arm, First in Human (FIH) clinical study to assess safety and efficacy of the CorNeat Keratoprosthesis, a synthetic cornea, for the treatment of corneal blindness

Terminated24 enrollment criteria

Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas

KeratoconusCorneal Diseases2 more

This study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (CXL) of asymmetric corneas.

Terminated15 enrollment criteria

Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem...

Corneal UlcerCorneal Disease1 more

Treatment of patients with inflammatory-dystrophic diseases of the cornea using autologous limbal stem cells (corneal epithelial stem cells) or adipose-derived mesenchymal stem cells

Completed12 enrollment criteria

Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus

KeratoconusCorneal Crosslinking5 more

The purpose of this study is to evaluate the efficacy, safety and postoperative ocular discomfort by comparing individually customized Photorefractive intrastromal crosslinking (PiXL) for progressive Keratoconus. The study compares two different protocols, PiXL with corneal epithelium debridement (Epi-off) and PiXL without epithelium debridement in high oxygen environment (Epi-on), with the hypothesis that Epi-on gives less postoperative ocular discomfort.

Completed13 enrollment criteria

Prospective, Single Center Switching Study of 0.0015% Tafluprost Ophthalmic Solution in Primary...

GlaucomaPrimary Open Angle

The objective of this study was to investigate the improving effect of corneal disorder in primary open-angle glaucoma and ocular hypertension patients, when switched from the 0.005% latanoprost ophthalmic solution (one drop at a time, once daily) to the 0.0015% tafluprost ophthalmic solution (one drop at a time, once daily). Efficacy also was investigated.

Completed16 enrollment criteria

Study of Dehydrex in Patients With Corneal Erosion

Corneal DiseasesRecurrence

This is a compassionate-use treatment study to provide Dehydrex to patients with corneal erosion syndrome who have previously used Dehydrex.

Completed17 enrollment criteria

Autologous Adipose-Derived Adult Stem Cell Implantation for Corneal Diseases (ADASCs-CT-CD)

Ophthalmological DisorderCorneal Dystrophy3 more

Cellular therapy of the corneal stroma with implantation of mesenchymal stem cells derived from autologous adipose tissue with or without a carrier (scaffold) composed by decellularized human donor corneal stroma is used in patients with corneal diseases such as corneal dystrophies, and keratoconus. For this purpose, the study planned to assess the enhancement of visual acuity, pachymetric, and aberrometric parameters with implantation of autologous mesenchymal adipose tissue-derived adult stem cells (ADASCs) alone, 120 µm thickness of decellularized or recellularized laminas with ADASCs. Three groups will be included in the study: (1) Implantation of a single dose of ADASCs alone without scaffold. (2) Implantation of decellularized human corneal lamina without ADASCs. (3) Implantation of the recellularized human corneal lamina with ADASCs.

Completed29 enrollment criteria

Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel

Contact Lens DiscomfortContact Lens-induced Corneal Disorder2 more

This study compares contact lens comfortable wear duration, and signs and symptoms of contact lens discomfort, test versus control.

Completed33 enrollment criteria
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