Alzheimer's in Long-Term Care--Treatment for Agitation
Alzheimer DiseasePsychomotor AgitationThe purpose of this study is to see if a medication called prazosin is useful in the treatment of agitation and aggression in persons with Alzheimer's disease (AD) and other types of dementia in late life.
Study of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type...
Alzheimer DiseaseThe purpose of this study is to assess xaliproden's potential capacity of slowing the deterioration of cognitive and global functions in patients with mild to moderate Alzheimer's disease. The patients participating in this study will take orally once daily xaliproden or placebo (inactive substance pill).
Depression in Alzheimer's Disease-2
Alzheimer's DiseaseDepressionThe purpose of this study is to learn whether treating individuals with Alzheimer's disease and depression with the anti-depressant medication sertraline (Zoloft) is helpful to people with Alzheimer's disease and to their families and caregivers.
Translating a Dementia Caregiver Intervention Into a Mobile Application
DementiaAlzheimer Disease1 moreThe overall goal of this development project is to combine elements of two efficacious interventions into a mobile health (mHealth) App for informal dementia caregivers. The investigators will conduct a 3-month feasibility trial of the newly-developed CARE-Well App in 40 dementia caregivers to establish acceptability and feasibility of the intervention, study procedures, and outcome measures.
A Study to Compare the Pharmacokinetics of BR4002 and BR4002-1 in Healthy Volunteers
Dementia AlzheimersThis study is designed as a randomized, open-label, single-dose, 6x3 crossover study.
The BRAIN App: Building Relationships Using Artificial Intelligence and Nostalgia
DementiaDementia4 moreThis study will involve testing of an Alpha version of an app called "Building Relationships using Artificial Intelligence and Nostalgia" or BRAIN. The BRAIN App will be the first -ever artificial intelligence infused CST app for PWD. The app has two main goals: (1) to foster positive relationships between the care triad, and (2) to promote QoL while reducing responsive behaviors in PWD. Testing will examine the app's impact on engagement/affect for both PWD and professional Care Partners.
Insulin-Sensitizing Anti-Inflammatory Small Molecule for Investigative Treatment of Dementia
Alzheimer DiseaseThis study seeks to measure changes in cognition through verbal and visual test procedures and changes in biomarkers of Alzheimer's disease and inflammatory and metabolic parameters that can be measure in the central nervous system (CNS) with advanced neuroimaging techniques in patients treated with NE3107 (17a-ethynyl-androst-5-3b,7b,17b-triol).
Families Coping Together With Alzheimer's Disease
Family ResearchDementiaTwo remote phone/zoom calls are required to assess experiences as a family coping with dementia.
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
Alzheimer DiseaseMild Cognitive ImpairmentThe purpose of this study is to learn about health care use, costs, and clinical outcomes over time for amyloid positive participants with early stages of AD in the United States. This study is for research purposes only, and is not intended to treat any medical condition. No study therapy(ies) for AD will be administered.
Early Identification of Markers in Alzheimer's Families / ALFA
Alzheimer's DiseaseThe ALFA study is a long term, prospective, observational study of AD patients' adult children aimed at studying and characterizing key physio-pathological features of the preclinical phase of AD.