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Active clinical trials for "Depression, Postpartum"

Results 161-170 of 375

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

Depressive DisorderDepression9 more

A clinical study to evaluate safety, tolerability and efficacy of oral administration of ganaxolone in women with postpartum depression

Completed8 enrollment criteria

Insomnia and Rumination in Late Pregnancy and the Risk for Postpartum Depression

InsomniaPost Partum Depression

The primary objective of the proposed research is to determine whether prenatal insomnia and ruminative thinking predict severity of postpartum depression (PPD) symptoms. Additionally, the investigators will also determine the effectiveness of digital/internet-based Cognitive Behavioral Therapy for Insomnia (dCBTI) in reducing the risk for PPD.

Completed8 enrollment criteria

A Study to Assess the Safety of Brexanolone in the Treatment of Adolescent Female Participants With...

Post Partum Depression

This is a multi-center study evaluating the safety, tolerability, and pharmacokinetics of brexanolone in the treatment of adolescent female participants with postpartum depression (PPD).

Completed8 enrollment criteria

1-Day CBT Workshops for PPD

Postpartum Depression

Postpartum depression (PPD) affects up to 20% of women and has profound effects on women and their families. Clinical practice guidelines recommend that the majority of women with PPD receive psychotherapy. A previously validated 1-day CBT workshop has been adapted for depression for use with women experiencing PPD and living in the community. 476 women will be randomized to active treatment or a 12 week wait list in each setting and compare changes in depression, mother-infant attachment, service utilization, quality of life, and offspring behaviour.

Completed4 enrollment criteria

Behavioural Interventions for Postnatal Depression: a RCT Study

Postnatal Depression

Randomized-controlled trial on the effectiveness of managing postnatal depression mothers at primary care clinics using Cognitive-behavioural therapy treatment by nurses as adjunct to management by Medical Officer as compared to Medical Officer alone

Completed6 enrollment criteria

Peer Administered CBT for PPD

Postpartum Depression

Postpartum depression (PPD) affects up to 20% of women and has profound effects on mothers and their infants. Unfortunately, fewer than 15% of women with PPD receive evidence-based care. This is at least partly due to significant difficulties faced by women in accessing cognitive behavioural therapy (CBT), a preferred 1st line treatment. In Ontario at present, there is a significant lack of personnel trained to deliver CBT. This study will utilize a randomized controlled trial design (with wait list controls) and recruit 70 participants to determine if women with a past history of PPD (i.e., lay peers) can be trained to deliver effective group CBT to women with current PPD. If peers can be trained to provide effective CBT, more women would receive treatment and the burden of PPD on women, families, and the healthcare system would be significantly reduced.

Completed2 enrollment criteria

The Effects of Light Therapy on Circadian Rhythms, Sleep, and Mood in Postpartum Depression

DepressionPostpartum

The proposed study aims to establish the feasibility of light therapy for postpartum depression delivered via Re-Timer, demonstrate its preliminary efficacy, and illuminate relationships between circadian shifts and mood changes using a novel, home-based circadian biomarker assessment paradigm (salivary dim light melatonin onset; DLMO).

Completed11 enrollment criteria

Measuring and Reducing Excessive Infant Crying

Infant ColicPostpartum Depression

Excessive infant crying (EIC) is likely to increase the risk of child abuse. The investigators propose a randomized trial using an intervention based on recommendations of Karp. The investigators will systematically identify 170 term infants with EIC and conduct assessments in the home at 6-8 weeks age to test the hypothesis that the intervention reduces mean infant hours of night-time crying, increases maternal soothing behaviors and improves parental anxiety and depression.

Completed6 enrollment criteria

The Effect of Exercise on Preventing PostPartum Depression

PostPartum Depression

The purpose of this study is to examine the feasibility and efficacy of an exercise intervention for the prevention of postpartum depression. If efficacious, our intervention could be disseminated in "real world settings" in an effort to prevent postpartum depression.

Completed16 enrollment criteria

Use of Omega-3 Fatty Acids for Perinatal Depression

DepressionDepression1 more

This study will evaluate the effectiveness of using omega-3 fatty acids to treat women with perinatal depression.

Completed10 enrollment criteria
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