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Active clinical trials for "Depressive Disorder, Treatment-Resistant"

Results 61-70 of 336

Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal...

Major Depressive DisorderTherapy Resistant Depression

Pragmatic clinical trial of an add-on therapy regarding the use of edupression.com® - a licensed computer based self-help program - on patients with therapy-resistant depression receiving esketamine nasal spray

Recruiting9 enrollment criteria

PCS in Severe Treatment Resistant Depression

Treatment Resistant Depression

This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms. Participants receive intermittent electrical stimulation to the brain, which involves surgically placing electric leads in between the tough fibrous membrane covering the surface of the brain and the surface of the brain itself. This type of stimulation is referred to as bilateral subdural prefrontal cortical stimulation (PCS) because it will specifically target the outer layer of the brain at the midline, right behind the forehead. It uses a pacemaker-like device, the Proclaim Elite SCS System (Abbott Laboratories) for stimulation. Although the U.S. Food and Drug Administration (FDA) has approved the system for brain stimulation for patients with chronic pain and muscular diseases, such as Parkinson's, its use is still investigational, and the surgery is still experimental for patients who have depression.

Recruiting25 enrollment criteria

A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine...

Treatment Resistant Depression

This study will be conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 2b study. Approximately 180 subjects with treatment resistant depression who meet all eligibility criteria will be enrolled.

Recruiting53 enrollment criteria

An Intervention Study of Anhedonia and Pain Empathy in Depression

Treatment Resistant DepressionProblem Management Plus1 more

Brain Network Mechanism of Pain Empathy and Anhedonia in Patients With Depression by Group Problem Management Plus Intervention.

Recruiting8 enrollment criteria

Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study

Treatment Resistant Depression

This study evaluates the effectiveness of re-treatment using accelerated schedule of intermittent theta-burst stimulation for treatment-resistant depression. This is an open label study.

Enrolling by invitation13 enrollment criteria

Near-Infrared Laser Stimulation for Various Neurological Conditions

Refractory DepressionAnxiety Disorders3 more

The study will evaluate the safety and feasibility of near infrared therapy as an intervention for patients with refractory depression, anxiety, neurodegenerative disease, and traumatic brain injury.

Enrolling by invitation28 enrollment criteria

Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders

SchizophreniaTreatment Resistant Depression2 more

This pilot open-label study examines the effects of a combination of dasatinib plus quercetin - two drugs that have known senolytics properties - on physiological aging in older individuals with depression or schizophrenia.

Recruiting9 enrollment criteria

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

Major Depressive DisorderTreatment Resistant Depression1 more

This is a feasibility study and the goal of this project is to evaluate whether peak ACC GABA and glutamate, quantified as a CSF-corrected absolute concentration percent change from baseline, is associated with clinical remission, Montgomery Asberg Depression Rating Scale (MADRS) total score of <10, to the anti-glutamatergic antidepressant ketamine. As MRS is expensive, we also aim to study a correlation between change in peripheral metabolites (GABA and glutamate) and central GABA and glutamate levels.

Enrolling by invitation36 enrollment criteria

Psilocybin-assisted Interpersonal Therapy for Depression

Depressive DisorderTreatment-Resistant

This is a single-arm, open-label interventional study of psilocybin-assisted interpersonal therapy for treatment resistant depression. 20 participants will be recruited to take part in this 8-week intervention that involves 8 sessions of psychotherapy and 2 doses of psilocybin.

Enrolling by invitation25 enrollment criteria

Glutamate Emotion Memory Study

Treatment Resistant DepressionDepression1 more

Clinical depression often includes a pessimistic view of things which have happened in the past and an impairment in the ability to experience pleasure or looking forward to things. A licensed drug called ketamine affects the levels of glutamate, a chemical messenger in the brain, and has been used as a treatment particularly for depression which hasn't got better with other types of medication. Glutamate plays a role in learning and memory so the investigators are interested in understanding how ketamine can affect how people with depression remember past negative and positive memories and how they experience reward. The investigators are conducting a study in depressed participants who did not improve with the standard antidepressant treatment to expand our understanding on how ketamine can influence memory, the way people understand emotions and learn from rewards and punishments. Study participants will undergo medical and psychiatric health screening, drug administration (ketamine or saline), questionnaires and computer tasks before and after the administration of the study drug, and an MRI scan after administration of the drug. MRI is a type of brain scan that allows us to see how the brain responds during for example memories of things which have happened in the past. This project will help us understand how NMDA antagonists may work in depression.

Recruiting40 enrollment criteria
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