Active clinical trials for "Depressive Disorder"

To examine differences in neurophysiologic parameters between unmedicated patients with bipolar depression and healthy controls To examine within-subject changes in neurophysiologic parameters in patients with bipolar depression treated with quetiapine

The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.

The major objective of this observational study is to describe clinical outcomes of patients in the UK receiving treatment with the NeuroStar TMS Therapy system in routine clinical practice.

Depression is very common in epilepsy. Depression is the strongest predictor of poor quality of life in patients with epilepsy. The biological basis for depression in epilepsy remains poorly understood. This study uses functional MRI (fMRI) to examine brain response to emotional and non-emotional stimuli in healthy control subjects and in patients with epilepsy who are either depressed or not depressed. Results from this study will contribute to a better understanding of depression in epilepsy, which may eventually inform development of better treatment modalities..

The primary objective of this prospective, blinded observational study is to correlate assessment of sedation and respiratory status with capnography and pulse oximetry monitoring in hospitalized adult medical and trauma patients receiving patient-controlled analgesia (PCA) or nurse administered intravenous (IV) opioids for acute pain. Nursing assessment of respiratory status and sedation level will be correlated with capnography and pulse oximetry values as technology-supported monitoring to identify respiratory depression and opioid-induced sedation. The secondary objective is to identify capnography and pulse oximetry values that correlate with respiratory decompensation and opioid-induced sedation in medical and trauma patients on the general care floor.

Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising, novel, non-invasive therapy for depression. The study is looking at changes in specific electroencephalogram parameters in depressed patients treated with rTMS can serve as predictors of depression treatment response among cancer patents undergoing rTMS treatment of depression.

This is a pre-approval access program (PAAP) for eligible participants. The main purpose of this program is to provide access to esketamine nasal spray to eligible participant with treatment-resistant depression (TRD), who have exhausted all other treatment options, including all alternative treatment options with marketed therapies.

This is an expanded access program intended to provide access to ZULRESSO™ (brexanolone) injection for the treatment of a limited number of eligible women with postpartum depression during the period prior to commercial availability. Requests for access must be made by a healthcare provider for a specific patient based on a determination with patient that the benefits of treatment outweigh the risks and an assessment of eligibility based on program criteria. Sites with eligible patients must apply and meet requirements for participation in the expanded access program.

Cognitive and emotional disorders are often encountered in multiple sclerosis (MS) cases: depressive and bipolar disorders are twice as frequent as in general population. Cognitive disorders, (particularly attention and dysexecutive disorders), appear in early stages of the disease's evolution, in cases of lightly or moderately disabled patients, with a recent evolution, with a "minor" form of the disease, even in Clinically Isolated Syndromes (CIS). Emotional disturbances are essentially linked to mood disorders of depression-type. Last ten years, emotional processing in multiple sclerosis cases was investigated in various trials, especially regarding the recognition of facial and emotional expressions. These studies reported data, supporting an impairment of the perception of emotion, particularly those with negative valence. The objective of this study is to investigate the link between recognition of facial and emotional expressions and depression in multiple sclerosis cases.

Background and significance: Though the problem of bullying among adolescents is evidently increasing and of a serious social concern, it is often undetected until serious outcomes have surfaced. In recent years, along with the rapid expansion of the Internet, social network services (SNS) and smart phones, "cyber-bullying" has been growing. Compared to the traditional bullying, cyberbullying is unique in nature and potentially more hazardous in terms of invisibility, lack of control, where it enables communication with a broad range of people at any time and place. To explore deeper understanding of the magnitude and the impact of the bullying among adolescents in Taiwan to inform public policy and future health intervention programs may be beneficial not only to Taiwan but also to Asia as a whole. Many Asian countries now suffer the similar problems of bullying among adolescents, since these countries share similar characteristics of development (spread of internet, SNSs and smart phones). Goal and objectives: This study aims to explore Taiwanese adolescents' experiences, perceptions, opinions and mental health regarding cyberbullying and traditional bullying to inform the development of questionnaire in the quantitative phase of mixed methods study. Study design: A qualitative study design with in depth interviews will be adopted. Target population and study setting: Senior high school students will be recruited from Taipei city, Taiwan. Sample size and sampling method: Participants will be sampled by convenience sampling until thematic saturation is attained, probably around 50 students. Data collection: Face-to-face in-depth interview with semi-structured questionnaire will be used. Data analysis: All interviews will be voice-recorded, transcribed, analyzed by thematic analysis procedure. Analysis process will include familiarization, coding, searching for themes, reviewing the themes, defining, naming themes and writing up or weaving the analytic narrative. Triangulation and supervision will also ensure credibility and balance in the process.