Active clinical trials for "Depressive Disorder"

Anxiety and depression are common comorbidities of chronic obstructive pulmonary disease (COPD). However, the exact prevalence is not known in China. COPD patients with anxiety and depression tend to have more severe symptoms and worse prognosis, but the related evidences are not strong enough. The study aim to investigate the prevalence and long-term outcome of anxiety and depression in COPD.

To assess the prevalence of anxiety / depression in post- hospital for parents (mothers and fathers) of children with tracheotomy before the age of 1 year between 2000 and 2012.

Background and significance: Though the problem of bullying among adolescents is evidently increasing and of a serious social concern, it is often undetected until serious outcomes have surfaced. In recent years, along with the rapid expansion of the Internet, social network services (SNS) and smart phones, "cyber-bullying" has been growing. Compared to the traditional bullying, cyberbullying is unique in nature and potentially more hazardous in terms of invisibility, lack of control, where it enables communication with a broad range of people at any time and place. To explore deeper understanding of the magnitude and the impact of the bullying among adolescents in Taiwan to inform public policy and future health intervention programs may be beneficial not only to Taiwan but also to Asia as a whole. Many Asian countries now suffer the similar problems of bullying among adolescents, since these countries share similar characteristics of development (spread of internet, SNSs and smart phones). Goal and objectives: This study aims to explore Taiwanese adolescents' experiences, perceptions, opinions and mental health regarding cyberbullying and traditional bullying to inform the development of questionnaire in the quantitative phase of mixed methods study. Study design: A qualitative study design with in depth interviews will be adopted. Target population and study setting: Senior high school students will be recruited from Taipei city, Taiwan. Sample size and sampling method: Participants will be sampled by convenience sampling until thematic saturation is attained, probably around 50 students. Data collection: Face-to-face in-depth interview with semi-structured questionnaire will be used. Data analysis: All interviews will be voice-recorded, transcribed, analyzed by thematic analysis procedure. Analysis process will include familiarization, coding, searching for themes, reviewing the themes, defining, naming themes and writing up or weaving the analytic narrative. Triangulation and supervision will also ensure credibility and balance in the process.

This research tries to investigate the validity and reliability of eye-tracking technologies by using different paradigms (eg. free-view, pro-saccade and anti-saccade) which served as a novel way of evaluating suicide risk among affective disorder patients including bipolar and unipolar depression. All the participants including health control will be assessed by clinical interviewing, self-report assessment, cognitive evaluation and eye-tracking task.

This study will try to provide a better understanding of the psychological, cognitive and electrophysiological factors that contribute to suicide in depressed patients.

Results of the study and of 5 years follow up of depressed patients who participated in the study during 2014-2015. We will locate the participants and will interview them will use the same questionnaires to evaluate their depressive symptoms. We will also measure the time to relapse.

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records

Major depressive disorder (MDD) is a common mental illness with high prevalence and global burden. Previous studies revealed that over 70% patients in remission still had decreased quality of life, severe function impairment, low positive mental health score and poor coping ability. However, few studies focus on working and school age patients with MDD. A GBD survey showed that over 40% MDD patients are 15-50 years old. Therefore, we initiate the present multi-center cross-sectional survey to investigate the associations between clinical symptoms, cognitive function, occupational/study ability, and quality of life in Chinese working and school age population with MDD who are in remission.

This project will combine the data collected from EEG, Eye tracking, structural and functional MRI scans and neuropsychological performance from patients with major depression receiving SSRI treatment. The purpose of this research is to predict the success of the SSRI treatment and to categorize patients into sub-groups according to similar patterns of brain activation to personalize treatment.

Patients over 65 years old who are exposed to alcohol or benzodiazepines will be recruited through the Fragility Assessment and Addictions Prevention Day Hospital, the Addiction Service and the Geriatric Post-Emergency Department. Toulouse University Hospital. The investigators will study descriptively the frequency of substance use disorder and the frequency of DSM-5 criteria associated with this diagnosis in a population of elderly subjects.