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Active clinical trials for "Diabetes Insipidus, Neurogenic"

Results 1-10 of 12

Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia...

Arginine Vasopressin DeficiencyPrimary Polydipsia

The aim of this study is to investigate whether oral urea stimulates copeptin release and, if so, whether it may provide a novel diagnostic test in the differentiation between AVP-D (Arginine vasopressin deficiency) and PP (primary polydipsia).

Recruiting16 enrollment criteria

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

HypopituitarismCentral Diabetes Insipidus6 more

Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function. Hypopituitarism is associated with increased obesity, increased psychopathology, sexual and prosocial dysfunction despite appropriate hormone replacement. A few studies suggest the existence of a possible OT deficient state in hypopituitarism. In animal models, glucagon-like peptide 1 (GLP1) has shown to increase OT release. This study is designed to evaluate OT values after administration of GLP1 in adults (healthy volunteers and patients with hypopituitarism). The investigators hypothesize that OT response will be blunted following GLP1 receptor agonist (GLP1-RA) in patients with hypopituitarism compared to healthy controls.

Recruiting19 enrollment criteria

Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)

HypopituitarismCentral Diabetes Insipidus6 more

Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function. Hypopituitarism is associated with increased obesity, increased psychopathology, sexual and prosocial dysfunction despite appropriate hormone replacement. A few studies suggest the existence of a possible OT deficient state in hypopituitarism. In animal models, corticorelin hormone (CRH) has shown to increase OT release. This study is designed to evaluate oxytocin values after administration of CRH in adults (healthy volunteers and patients with hypopituitarism). The investigators hypothesize that OT response will be blunted following CRH in patients with hypopituitarism compared to healthy controls.

Recruiting17 enrollment criteria

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Central Diabetes Insipidus (cDI)

This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) to improve psychological symptoms and socio-emotional functioning. Optionally, patients can present for additional assessments in sub-studies: fMRI sub-study at day 14 (± 2 days) (one additional visit) Social-stress sub-study at day 14 (± 2 days) (one additional visit)

Not yet recruiting11 enrollment criteria

Seoul National University Pituitary Disease Cohort Study

Pituitary DiseasePituitary Incidentaloma6 more

The purpose of this study is to investigate the treatment and natural history of pituitary disease. We have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning pituitary adenoma. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary tumor tissue (when available through clinical care) will be saved for future analyses related to pituitary disease.

Recruiting4 enrollment criteria

Effects of Intranasal Oxytocin in Patients With Central Diabetes Insipidus

Central Diabetes Insipidus

This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (4 IU and 24 IU) in 18-60-year-old men and women with central diabetes insipidus to evaluate the effect of oxytocin on anxiety, depression and socioemotional functioning. Following a screening visit to determine eligibility, participants will return for three main study visits. During the main study visits, study participants will receive either oxytocin or placebo, followed by assessments of emotional behavior. Thirty participants will be equally randomized to one of six possible drug orders: 4 IU oxytocin - 24 IU oxytocin - placebo 4 IU oxytocin - placebo - 24 IU oxytocin 24 IU oxytocin - 4 IU oxytocin - placebo 24 IU oxytocin - placebo - 4 IU oxytocin placebo - 4 IU oxytocin - 24 IU oxytocin placebo - 24 IU oxytocin - 4 IU oxytocin

Not yet recruiting16 enrollment criteria

Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)

Oxytocin DeficiencyHypopituitarism4 more

Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function. Hypopituitarism is associated with increased obesity, increased psychopathology, sexual and prosocial dysfunction despite appropriate hormone replacement. A few studies suggest the existence of a possible OT deficient state in hypopituitarism. In animal models, melatonin has shown to increase OT release. This study is designed to evaluate oxytocin values after administration of melatonin in adults (healthy volunteers and patients with hypopituitarism). The investigators hypothesize that OT response will be blunted following melatonin in patients with hypopituitarism compared to healthy controls.

Not yet recruiting17 enrollment criteria

A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).

Central Diabetes Insipidus

This is an open-label dose-titration study in Japanese Central Diabetes Insipidus (CDI) patients designed to demonstrate the efficacy and safety of orally-disintegrating tablet of desmopressin.

Completed23 enrollment criteria

Electrophysiology of the Human Pituitary Gland

Pituitary AdenomaPituitary Tumor2 more

Measurment of electrophysiological properties of the human pituitary gland during removal of a pituitary adenoma. Assessment if these properties are sufficient for intra-operative identification of different tissues.

Terminated7 enrollment criteria

Vasopressin Deficiency in Hemorrhagic Shock

Body Response to Trauma

In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.

Completed7 enrollment criteria
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