Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery
Sellar and Suprasellar MassesPituitary TumorAccess the optimal cut point value of copeptin which predicts development of central diabetes insipidus postoperatively with highest accuracy. Access the optimal cut point value of copeptin which predicts the lack of central diabetes insipidus postoperatively with highest accuracy Access the relative change in copeptin values between baseline and post-surgery as a predictor for diabetes insipidus development.
Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus
Diabetes InsipidusDiabetes Insipidus1 moreOBJECTIVES: I. Determine whether diverse mutations of the vasopressin-neurophysin II (AVP-NPII) gene cause autosomal dominant familial neurohypophyseal diabetes insipidus by directing the production of an abnormal preprohormone. II. Determine whether the AVP-NPII gene-directed preprohormone accumulates and destroys magnocellular neurons because it cannot be folded and processed efficiently.