Delayed Mycophenolate Mofetil in Single-Donor Islet Allotransplantation in Type 1 Diabetes
Type 1 DiabetesHypoglycemiaThe objective of this study is to assess the safety and efficacy of islet allotransplantation for the reestablishment of stable glycemic control in patients with type 1 diabetes, using anti-thymocyte globulin induction immunosuppression with sirolimus, mycophenolate mofetil and low dose tacrolimus maintenance immunosuppression.
Behavior Therapy for Families of Diabetic Adolescents
Type 1 Diabetes MellitusEffective adaptation to type 1 diabetes mellitus requires adolescents and their families to work together effectively to solve problems and resolve disagreements in order to achieve acceptable diabetic control and treatment adherence. Many studies show that problematic family communication, insufficient parental involvement in care and parent-adolescent conflict are associated with poor adherence and poor diabetic control. This study tests a family communication and problem solving intervention by randomizing families of adolescent with type 1 diabetes to 6 months' treatment either with the experimental intervention, continuation in standard medical care for diabetes, or participation in a multifamily educational support group. Families are then followed for an additional 12 months to examine the longer-term effects of the interventions on the targeted diabetes outcomes.
The Effect of Cinnamon on HbA1c Among Adolescents With Type I Diabetes
Type 1 Diabetes Mellitusthe purpose of this study is to determine if cinnamon improves glucose control among adolescents with type 1 diabetes mellitus.
Efficacy and Safety of Biphasic Insulin Aspart 30 in Type 1 or 2 Diabetes
DiabetesDiabetes Mellitus3 moreThis trial is conducted in Asia. The aim of this trial is to investigate the efficacy of biphasic insulin aspart 30 on postprandial glycaemic control.
Safety Follow-up on Children and Adolescents With Type 1 Diabetes Treated With Insulin Detemir....
DiabetesDiabetes Mellitus1 moreThis trial is conducted in Europe. The aim of this research is to assess the safety of continuous treatment with insulin detemir following participation in trial NN304-1689 (NCT00435019) on antibody development.
Safety and Efficacy of Insulin Detemir Plus Insulin Aspart Against Insulin Glargine Plus Insulin...
DiabetesDiabetes Mellitus1 moreThis trial is conducted in Europe and the United States of America (USA). The purpose of this study is to test whether insulin detemir is a safe and at least as effective alternative to insulin glargine for the control of blood glucose in basal/bolus therapy in patients with type I diabetes.
To Examine the Lung When People With Diabetes Take an Inhaled Form of Insulin, Compared to Subcutaneous...
Diabetes MellitusType 1To examine the lung when people with diabetes take an inhaled form of insulin, compared to subcutaneous insulin.
Safety and Efficacy of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes Mellitus....
Diabetes MellitusType 1This is a research study of a study drug known as LY041001 or human insulin inhalation powder (HIIP). HIIP is a powder form of insulin made to be inhaled through the mouth and into the lungs using a special handheld device.
Insulin Aspart vs. Insulin Lispro vs. Regular Insulin in Paediatric Population
DiabetesDiabetes Mellitus1 moreThis trial is conducted in the United States of America (USA). The aim of this trial is to to determine whether insulin aspart can be used effectively and safely in paediatric patients.
Effects of Vitamin B1 in Type 1 Diabetic Patients
Diabetes MellitusType 1The purpose of this study is to determine whether benfotiamine supplementation can reduce markers of microvascular complications in type 1 diabetic patients.