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Active clinical trials for "Intervertebral Disc Degeneration"

Results 201-210 of 415

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine

Intervertebral Disc DiseaseIntervertebral Disc Degeneration3 more

The purpose of this study is to determine whether NuCel is effective in promoting spinal fusion in degenerative disease of the lumbar spine.

Completed13 enrollment criteria

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical...

Cervical Degenerative Disc DiseaseDegenerative Spondylolisthesis1 more

The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in subjects with a diagnosis of degenerative disc disease (DDD) at 2 or more adjacent cervical vertebral levels between C3-C4 to C7-T1. All subjects in this study will undergo 2 or 3 level anterior cervical discectomy and fusion with anterior cervical plate fixation.

Completed20 enrollment criteria

Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two...

Cervical Degenerative Disc DiseaseRadiculopathy1 more

The purpose of this clinical investigation is to assess the safety and effectiveness of using the PRESTIGE-LP device in the treatment of patients with symptomatic degenerative disc disease at two adjacent levels of the cervical spine, with overall success being the primary endpoint of the clinical trial. The primary objective is to show non-inferiority of the investigational device to the control treatment. If non-inferiority is established, superiority will also be examined as the secondary objective.

Completed37 enrollment criteria

OptiMesh® for Lumbar Interbody Fusion Trial (OLIF)

Degeneration of Lumbar Intervertebral Disc

The purpose of this study was to collect data to demonstrate the safety and effectiveness of the OptiMesh 1500S to contain and reinforce bone graft materials in patients with Degenerative Disc Disease (DDD) whose condition requires an interbody spinal fusion procedure combined with posterior fixation.

Completed26 enrollment criteria

Cervical I/F Cage for Anterior Cervical Fusion

Cervical Intervertebral Disc Degeneration

The purpose of this study is to determine the clinical success of the Cervical I/F Cage in treatment of one or two adjacent levels of degenerative disc disease of the cervical spine compared with standard of care treatment using either autograft, autograft with a plate or allograft with a plate

Completed12 enrollment criteria

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

Degenerative Disc Disease

The purpose of this study is to determine the clinical success of DePuy Spine Titanium Surgical Mesh with MOSS Miami Spinal Fixation System Pedicle Screws in the treatment of one or two levels of degenerative disc disease of the lumbar spine. The observed success rate at 24 months will be compared to an historical control group treated with the Lumbar I/F Cage with VSP System.

Completed10 enrollment criteria

Pivotal IDE Study of the BRYAN(R) Cervical Disc Prosthesis in the Treatment of DDD Versus ACDF

RadiculopathyMyelopathy1 more

The purpose of this study is to establish the safety and effectiveness of the BRYAN(R) Cervical Disc Prosthesis in treating single-level degenerative disc disease of the cervical spine.

Completed27 enrollment criteria

Safety and Efficacy Study Comparing ProDisc-C to ACDF Surgery to Treat SCDD

Symptomatic Cervical Disc Disease

The objective of this clinical investigation is to compare the safety and effectiveness of ProDisc-C to anterior cervical discectomy and fusion (ACDF) surgery in the treatment of symptomatic cervical disc disease (SCDD).

Completed24 enrollment criteria

LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE

Degenerative Disc Disease

The purpose of this investigation is to establish the safety and effectiveness of the LDR Spine Mobi-C® Cervical Disc Prosthesis which is an anterior cervical interbody mechanical device. The primary objective of the study is to evaluate the overall success rate of the investigational device as compared to the control in the treatment of patients with symptomatic DDD with radiculopathy or myeloradiculopathy at one or two adjacent levels. Patients should be without prior cervical fusion between C3 and C7 and unresponsive to non-operative conservative treatment for six weeks after symptom onset or have the presence of progressive symptoms or signs of nerve/spinal cord compression despite continued non-operative conservative treatment.

Completed26 enrollment criteria

Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease

Degenerative Disc Disease

The purpose of this study is to determine the safety and effectiveness of HEALOS compared with autograft using the transforaminal lumbar interbody fusion (TLIF) method.

Completed8 enrollment criteria
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