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Active clinical trials for "Kidney Failure, Chronic"

Results 51-60 of 1823

Benefits of Hemodialysis Plus Hemoperfusion: A Clinical Study

End Stage Renal Disease

This multi-center, open-label, randomized, parallel controlled trial aims to investigate the efficacy of hemoperfusion (HP) in combination with hemodialysis (HD) by assessing blood β2-microglobulin (β2-MG), parathyroid hormone (PTH) and C reactive protein (CRP) clearance in maintenance hemodialysis patients.

Recruiting19 enrollment criteria

Immunological Tolerance in Patients With Mismatched Kidney Transplants

End Stage Kidney DiseaseImmunological Tolerance2 more

This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3 antigen (at A, B, C, DR) HLA mismatched unrelated living donor kidney and hematopoietic stem cell transplantation.

Recruiting74 enrollment criteria

Evaluation of STARgraft-3 for Hemodialysis

End Stage Renal Disease

This study is a single site, prospective, single arm evaluation of the safety and effectiveness of the Healionics STARgraft-3 hemodialysis access graft. STARgraft devices have been demonstrated in preclinical and other studies to have improved resistance to the common failure modes of venous anastomosis stenosis and infection. This study is an extension from prior studies with STARgraft AV (NCT03916731) and STARgraft-2 (NCT04783779) investigational devices. A previous study also included control implants of commercially available standard ePTFE grafts approved for the same use. The study is enrolling patients with End Stage Renal Disease (ESRD) requiring hemodialysis via a prosthetic vascular graft. The study proposes to evaluate the performance of the investigational STARgraft-3 compared to the ePTFE controls in the prior study and to published results, over a period of 6 months, with extended results to 1 year. Estimated enrollment is 15 subjects in this study.

Recruiting26 enrollment criteria

A Study of MK-2060 in Participants With Chronic Kidney Disease (MK-2060-011)

End-Stage Renal DiseaseEnd-Stage Kidney Disease2 more

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single subcutaneous dose of MK-2060 in stage 4 chronic kidney disease (CKD4) participants. The primary hypothesis is that the true geometric mean of the area under the concentration-time curve from 0 to infinity (AUC0-inf) after a single-dose of MK-2060 in adult CKD4 participants is at least 1130 nM*hr.

Recruiting12 enrollment criteria

Efficacy and Safety of XyloCore Peritoneal Dialysis Solution.

End Stage Renal Disease

Randomized, controlled, parallel groups, open-label, blinded end-point assessment, multicenter study, comparing the effects of a low glucose peritoneal dialysis solution, XyloCore, to glucose solutions (Physioneal, Fixioneal, Dianeal, Balance, Bicavera, Bicanova or Equibalance) only regimen, in patients with End-Stage Renal Disease (ESRD) receiving Continuous Ambulatory Peritoneal Dialysis (CAPD), over a 6-month study period.

Recruiting26 enrollment criteria

Impact of Envarsus XR® on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile

End Stage Renal Disease

This will be a single center, prospective, open-label, randomized, controlled trial comparing Envarsus XR® to twice-daily tacrolimus. The targeted population will be patients with end stage renal disease listed for primary solitary kidney transplant. Transplant Surgery is not part of the study.

Recruiting18 enrollment criteria

Pain Reduction Using NEurostimulation Study

End Stage Kidney DiseaseChronic Pain

This is a 4-year project to see if a small battery-powered, device attached to a headband, that sits on the skin surface and delivers what is a hardly noticeable level of electrical stimulation can reduce pain in patients who receive hemodialysis on an ongoing basis.

Recruiting19 enrollment criteria

Study of a Dialysate Without Acetate on Protein Energy Wasting Syndrome in Chronic Hemodialysis...

End Stage Renal DiseaseHemodialysis

This work aims to study the effect of an acetate-free dialysate on protein-energy wasting syndrome in patients with chronic hemodialysis renal failure, in comparison to a conventional dialysate with acetate. The hypothesis is that a dialysate without acetate would improve patients nutritional status

Recruiting12 enrollment criteria

The Arteriovenous Vascular (AV) ACCESS Trial

End-Stage Kidney DiseaseHemodialysis Complication

This study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions

Recruiting17 enrollment criteria

Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

Kidney DiseaseEnd-Stage2 more

A prospective, single-arm, multi-center post-market surveillance study of the BD® WavelinQ™ EndoAVF System for the Creation of Arteriovenous (AV) Fistula in Patients Requiring Dialysis.

Recruiting23 enrollment criteria
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