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Active clinical trials for "Hyperinsulinism"

Results 41-50 of 89

Effects of a Comprehensive Weight Management Program on Obese Adolescents and Children

Pediatric ObesityInsulin Resistance1 more

To compare anthropometric and metabolic effects of a comprehensive weight management program on obese adolescents and children in comparison to regular clinical weight management visits.

Completed11 enrollment criteria

Phase II Long Term, Randomized Study of Recombinant Human Insulin-like Growth Factor I in Children...

Hyperinsulinism

OBJECTIVES: Evaluate the safety and efficacy of long term recombinant human insulin-like growth factor I in children with hyperinsulinism.

Completed2 enrollment criteria

Open-label Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism...

Congenital Hyperinsulinism

The objective of the trial is to evaluate the efficacy of dasiglucagon administered as a subcutaneous (SC) infusion in reducing hypoglycemia in children with CHI.

Completed17 enrollment criteria

The Effect of Andrographis Paniculata to GLP-1, Fasting Insulin, Insulin 2-h Post OGTT, and HOMA-IR...

Increased Insulin

Prevalence of type 2 diabetes have been increased, but medications had not been well, so that needed new alternatives. A new approach used in management of type 2 diabetes is incretin based therapy. Incretin hormone, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotrophic peptide (GIP), had producted in intestine due to carbohydrate intralumen. After had secreted, GLP-1 had degradated by DPP-4 enzyme till number and effect had been decreased. Decreasing of GLP-1 effect as main defect in type 2 diabetes. Andrographis paniculata (A. paniculata) as traditional treatment had known since years ago to have hypoglycemia effect. Extract of A. paniculata consists of andrographolid and flavonoid. Based on study of Wooten et al that flavonoid has hydroxyl to stimulate insulin's production through modulated GLP-1 receptor (GLP-1 receptor ligand). So the investigators need to study about The Effect of A. paniculata Extract to GLP-1, Fasting Plasma Insulin, Insulin concentrations measured during a standardized 2-h OGTT, and HOMA-IR.

Completed10 enrollment criteria

An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism

Congenital Hyperinsulinism

The objective of this trial is to evaluate the safety, tolerability and glucose-raising effects of RZ358 in patients with Congenital Hyperinsulinism (HI).

Completed13 enrollment criteria

Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes

Impaired Glucose ToleranceHyperinsulinism3 more

This study investigated any potential associations between two isocaloric diets with different meal frequency (3 meals versus 6 meals) and glycemic control in people at high diabetes risk (lean and overweight/obese women with PCOS, individuals with hyperinsulinemia, individuals with impaired glucose tolerance) and diagnosed with diabetes.

Completed5 enrollment criteria

Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity

Congenital Hyperinsulinism

The purpose of this study is to examine the effects of exendin-(9-39) on fasting blood glucose and protein induced hypoglycemia on subjects with Congenital Hyperinsulinism. Funding Source - FDA Office of Orphan Products Development (OODP).

Completed8 enrollment criteria

Dose Ranging Study of Recombinant Human Insulin-like Growth Factor I in Children With Hyperinsulinism...

Hyperinsulinism

OBJECTIVES: I. Determine the dose of recombinant human insulin-like growth factor I that minimizes or decreases the need for exogenous glucose support without causing hypoglycemia.

Completed6 enrollment criteria

Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy Diabetes

HyperinsulinismDiabetes2 more

This is a pilot study designed to determine if the bihormonal bionic pancreas provides improved blood glucose control, compared to the current standard of care, in individuals with hyperinsulinism who developed diabetes after having a pancreatectomy.

Completed24 enrollment criteria

Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism

Congenital HyperinsulinismHyperinsulinism3 more

Children with congenital hyperinsulinism (CHI) have low blood sugar, and some of these children may require surgery. In this study, researchers affiliated with the University of Pennsylvania will test how well a radioactive drug (called F-DOPA) can detect a form of hyperinsulinism that may be cured by surgery. Eligible participants in this study will have positron emission tomography (PET) scans with F-DOPA prior to surgery.

Completed3 enrollment criteria
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