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Active clinical trials for "Gastroesophageal Reflux"

Results 141-150 of 878

Evaluation of Esomeprazole in Treating Gastro-esophageal Reflux Disease (GERD) in Head and Neck...

Gastro-esophageal Reflux

The purpose of this research study is to measure acid reflux into the throat both before and after medical treatment in people who have had radiation therapy to their head and neck for the treatment of cancer. Many people who have received head and neck radiation therapy develop a dry mouth as a result of the radiation damage to their saliva glands. In addition to the discomfort associated with a dry mouth, the decrease in saliva may increase the severity of gastro-esophageal reflux disease (acid reflux). Acid reflux occurs when acid escapes from your stomach into your throat. You may not have any symptoms of acid reflux, but often it can cause symptoms of heartburn or chest discomfort. Acid reflux can be treated once it is diagnosed. Treatment consists of dietary changes, behavioral alterations, and medication. Medications are available that decrease the amount of acid in your stomach. Diagnosis of acid reflux is made with a pH-probe to test for acid in your throat.

Terminated17 enrollment criteria

A Trial of Thickened Feeds to Treat Gastroesophageal Reflux in Children Admitted After Choking Spell...

Apparent Life Threatening EventGastroesophageal Reflux1 more

Infants often present to the hospital with episodes of coughing, choking, gagging, change in muscle tone, and/or change in skin color, known as brief resolved unexplained event. Many studies have tried to address why infants have these symptoms and if there is a way to prevent them from happening again. Currently, there is no clear agreement on the most common cause of these symptoms or how to prevent them. Some studies have suggested that gastroesophageal reflux can cause these symptoms. The investigators are conducting a study of infants who are admitted to Boston Children's Hospital with episodes of coughing, choking, gagging, change in muscle tone, and/or change in skin color, symptoms that could be reflux. The investigators want to determine if these symptoms can be prevented by changing the way infants are fed, either by giving them a formula to treat reflux or by thickening their feeds to treat reflux. The goal of the study is to determine if different types of feeding interventions prevent infants from coming back to the hospital.

Terminated5 enrollment criteria

Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to...

Exercise Triggered AsthmaGastroesophageal Reflux

We propose that acid reflux affects respiratory dynamics (breathing) in patients who are exercising and that athletes improve their exercise capacity with acid suppression therapy. It is our intent to determine whether treatment of GER with strong acid suppression may alleviate symptoms, improve exercise capacity, and improve quality of life.

Terminated11 enrollment criteria

The Effects of Dexlansoprazole for the Treatment of Throat-Related Reflux

Laryngopharyngeal Reflux

Recent studies have demonstrated that patients with throat-related reflux often require twice daily proton pump inhibitor therapy to attain significant symptomatic improvement, with once daily therapy offering little relief. As dexlansoprazole is a twice-daily release proton pump inhibitor requiring only once-daily dosing, it may provide laryngopharyngeal reflux (LPR) symptomatic relief comparable to that of twice daily dosing, yet be more readily approved by third party payers because of its once daily dosing requirements. It is hypothesized that, in patients with pharyngeal-probe proven throat reflux, there will be significantly greater improvement in symptoms and pharyngeal probe findings in those patients receiving dexlansoprazole than those receiving placebo alone.

Terminated0 enrollment criteria

Determination of the Left Paratrachéal Force Required to Occlude the Esophageal Entrance

Oesophageal Reflux

Determine the force required to occlude the esophagus with a left paratracheal pressure

Not yet recruiting5 enrollment criteria

The CONQUEST-Study. Evaluation of Clinical Endpoints for Treatment-induced Changes in GERD-related...

Gastroesophageal Reflux DiseaseNon-erosive Reflux Disease

The aim of the study is to compare two different endpoint measures: heartburn as assessed by the physicians versus gastroesophageal reflux disease (GERD)-related symptoms as assessed by the patient using the ReQuest™ questionnaire. The assessment is made in GERD-patients treated with a daily dose of 40 mg oral pantoprazole over an 8-week period.

Terminated11 enrollment criteria

Effects of Victoza® Versus Lyxumia® on Gastroesophageal Reflux, Gastric Emptying and Gastric Acid...

Diabetes Mellitus

The present study will compare lixisenatide and liraglutide in a population of subjects with T2DM not optimally controlled on OADs and / or insulin, which is the target population for these medications.

Terminated6 enrollment criteria

Is Laparoscopic Fundoplication Better Than Open Fundoplication in Children ?

Gastroesophageal Reflux

The aim of the study was to compare short- and longterm outcomes after laparoscopic and open Nissen fundoplication in children.

Terminated6 enrollment criteria

Transoral Incisionless Fundoplication Database Repository (TIF)

Gastroesophageal Reflux Disease

Collect data on individuals who have a transoral incisionless fundoplication (TIF) performed by physicians at Indiana University for the treatment of gastroesophageal reflux disease.

Enrolling by invitation2 enrollment criteria

The Johns Hopkins Heartburn Center Registry

Gastroesophageal Reflux DiseaseBarrett Esophagus2 more

A multi-center, multi-year registry of patients with gastroesophageal reflux disease (GERD) undergoing diagnostic evaluation and/or treatment of GERD and associated diseases and complications.

Enrolling by invitation2 enrollment criteria
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