Phase I Study in Healthy Male Subjects Comparing QGC001 to Placebo
Essential HypertensionQGC001/1QG1 is a Phase I "first time in man" study aiming to determine the overall safety and tolerability of single ascending oral doses of QGC001 in healthy male subjects compared to placebo, as well as the pharmacokinetics of QGC001 and its metabolite EC33 and the pharmacodynamic properties of QGC001 (effects on the renin-angiotensin-aldosterone system, blood pressure and heart rate) in healthy male subjects.
Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension
HypertensionThe purpose of this study is to determine Korean red ginseng (KRG)treatment could decrease central blood pressure in subjects with hypertension.
A Study to Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Fimasartan in Healthy...
Essential HypertensionThe purpose of this study is to evaluate the effect of atorvastatin on the pharmacokinetics of fimasartan.
A Study to Evaluate the Safety and Pharmacokinetics After Oral Concurrent Administration of Fimasartan...
Essential HypertensionTo evaluate drug-drug interaction between fimasartan and hydrochlorothiazide.
HIRREM for Stage 1 Primary Hypertension
HypertensionBlood Pressure3 moreThe purpose of this study is to determine that effects of an intervention called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), on Stage 1 Primary Hypertension (systolic BP 130-139, and/or diastolic BP 80-89).
Repurposing Colchicine to Improve Vascular Function in Hypertension
Essential HypertensionIn this project the potential beneficial effect of the drug colchicine on vascular reactivity and blood pressure will be assessed. Colchicine is a commonly used anti-inflammatory medication approved for the treatment of gout, Familial Mediterranean Fever and pericarditis in Denmark. The current project idea is based on accumulating evidence in the literature for a beneficial role of colchicine treatment in the prevention of cardiovascular disease in parallel with novel mechanistic insight from our own research. Recently, colchicine was associated with a lower risk of cardiovascular disease, including reduced myocardial infarctions, strokes and acute coronary syndrome . However, none of these trials have investigated the effect of colchicine on arterial tone or stiffness, changes to which may underlie the reduced risk of cardiovascular disease associated with colchicine. In support of the hypothesis that colchicine will improve vascular reactivity, a study in 1985 by Lagrue et al. found that daily, low-dose colchicine improved arterial stiffness in a small cohort of hypertensive patients. More recently, colchicine was shown to improve arterial stiffness in patients with Familial Mediterranean fever supporting a cardiovascular protective role of colchicine. Finally, colchicine is also proposed to have anti-inflammatory effects in the vascular system.
A Clinical Trial to Evaluate the Effect of Fimarsartan on Pharmacodynamics, Pharmacokinetics, and...
Essential HypertensionTo evaluate the effect of Fimarsartan on pharmacodynamics, pharmacokinetics, and the safety of warfarin in healthy male volunteers.
Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential...
Hypertension,EssentialSympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,
Use of Metabolomics to Differentiate the Antihypertensive Effect of Acupuncture From Sham Acupuncture...
Hypertension,EssentialTo assess the effect of acupuncture versus sham acupuncture on regulating the targeted metabolome of hypertensive patients.
Pivotal Bioequivalence FDC Nifedipine / Candesartan vs. Loose Combination of Single Components,...
HypertensionEssentialRandomized, open label, single dose, 2-way crossover study to investigate the bioequivalence of a new fixed dose combination (FDC) tablet of nifedipine GITS and candesartan with the corresponding loose combination under fed conditions.