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Active clinical trials for "Dry Eye Syndromes"

Results 621-630 of 976

Femtosecond Small Incision Lenticular Extraction in Comparison to Femtosecond Laser Insitu Keratomileusis...

Dry Eye Disease

Comparison of femtosecond small incision lenticule extraction (FS-SMILE) versus Femtosecond laser Insitu Keratomileusis (FS-LASIK) regarding dry eye disease (DED) and corneal sensitivity (CS) after those refractive surgeries.

Completed8 enrollment criteria

Effect of Cequa™ in Subjects With Dry Eye Disease

Dry Eye Disease

This is a Phase 4, multicenter, single arm, 12 week study in subjects with dry eye disease, which is inadequately controlled by cyclosporine 0.05% ophthalmic emulsion.

Completed9 enrollment criteria

Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate...

Dry Eye Disease

Patients with mild to moderate dry eye disease will be randomized to receive either NovaTears® or Hydrabak® eye drops as control.

Completed10 enrollment criteria

Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops

Dry Eye SyndromesKeratoconjunctivitis Sicca6 more

Cross-over comparison of lipid layer thickness and dry eye symptoms with two artificial tear formulations.

Completed16 enrollment criteria

Total30 Sphere Contact Lenses

Contact Lens ComplicationDry Eye

The purpose of this study is to map comfort over the full wear day in established, asymptomatic, soft CL wearers who are refit in Total30 Sphere CLs.

Completed16 enrollment criteria

Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops

Dry Eye Syndrome

The objective of the study is to demonstrate a change in osmolarity over time when moderate to severe dry eye subjects are treated with TheraTears lubricating drops.

Completed17 enrollment criteria

Civamide Nasal Solution for the Treatment of Dry Eye

Dry Eye

Keratoconjunctivitis sicca (KCS) or Dry Eye Syndrome is a disease of the surface of the eye, tear film, and related ocular tissues. Millions of people suffer from one form of the disease or another and its prevalence increases with age. Dry Eye Syndrome sufferers experience a broad range of symptoms including discomfort, irritation, burning, itching, redness, pain, gritty feeling, foreign body sensation, blurred vision and ocular fatigue. Civamide is a TRPV-1 receptor modulator that causes the initial stimulation of neuropeptide release and subsequent desensitization to further stimulation of the trigeminovascular system. This provides a pharmacological rational for intranasal route of administration for disorders mediated by the trigeminal nerve or involving the cranial nerve. In nine clinical studies of Civamide Nasal Solution, over 50% of the nearly 300 patients who received Civamide via intranasal administration experienced lacrimation (tearing). This led to the hypothesis that Civamide Nasal Solution might be an appropriate treatment for Dry Eye Syndrome.

Completed15 enrollment criteria

Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy Volunteers

Ocular PainDry Eye

The purpose of this study is to determine whether SYL1001 is safe for the prevention and treatment of ocular pain and dry eye syndrome.

Completed19 enrollment criteria

Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Lubricant Eye Gel

Dry Eye

The purpose of this study is to compare the comfort and blurriness of an investigational lubricant eye drop with a marketed lubricant eye gel.

Completed3 enrollment criteria

Acute Comfort and Blur of Systane Ultra and Systane

Dry Eye

To evaluate drop comfort, acceptability, preference and blue profile between two marketed artificial tears in both dry eyes and non-dry eye patient population.

Completed2 enrollment criteria
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