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Active clinical trials for "Eye Infections"

Results 1-10 of 31

Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous...

Eye InfectionsBacterial

The purpose of this research study is to find out how Avenova (0.01 % hypochlorous acid) works compared to Betadine (Povidone iodide) for reducing bacteria and patient discomfort in the eyes.

Recruiting18 enrollment criteria

Non-Inferiority of Gatifloxacin/Prednisolone Association vs Isolated Administration in Prevention...

Ocular Infection and Inflammation

The purpose of the study is to evaluate the safety and tolerance of the 0.3% gatifloxacin and 1.0% prednisolone acetate association in eye drops in the prevention of infection and inflammation after refractive surgery (Lasik) and also demonstrate the non-inferiority of the efficacy of this association compared to the administration of 0.3% gatifloxacin and 1.0% prednisolone acetate as isolated eye drops formulations. The study treatment is randomized, double-masked, with 2 parallel arms. Each patient's participation lasts 29 days, with 15 days of study treatment administration after the ocular surgery is performed. Candidates for the study are patients with indication for ocular refractive surgery (Lasik) for correction of visual acuity.

Completed9 enrollment criteria

Optimizing Preoperative Disinfection of Eyes

Eye Infections

Topical povidone-iodine (PI) is widely used as ocular antiseptic before and after surgery. The standard dose of 5% PI is however, associated with ocular irritation. We therefore want to test if a lower concentration of PI can be similarly efficacious in reducing bacterial growth while reducing ocular irritation.

Terminated7 enrollment criteria

Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation

Ocular InfectionsIrritations and Inflammations

The primary purpose of this study is to determine the efficacy and safety of KPI-121 ophthalmic suspension compared to placebo in subjects who have undergone cataract surgery. The efficacy and safety of two different concentrations and two different dosing regimens of KPI-121 are also being assessed.

Completed7 enrollment criteria

Study of the Ocular Safety After Repeated Instillations of T1225 1% or 1.5% Eye Drops in Healthy...

Eye InfectionsBacterial

To evaluate the ocular tolerance of T1225 1% and 1.5% eye drops versus vehicle after one instillation twice-daily (morning and evening), in one eye, during 3 days (from Day 0 to Day 2). To assess azithromycin tear, conjunctiva and plasmatic concentrations, after a 3-day treatment period

Completed15 enrollment criteria

Endophthalmitis Vitrectomy Study (EVS)

EndophthalmitisEye Infections

To determine the role of initial pars plana vitrectomy in the management of postoperative bacterial endophthalmitis. To determine the role of intravenous antibiotics in the management of bacterial endophthalmitis. To determine which factors, other than treatment, predict outcome in postoperative bacterial endophthalmitis.

Completed2 enrollment criteria

Steroids for Corneal Ulcers Trial

Corneal UlcerEye Infections1 more

The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.

Completed30 enrollment criteria

Ocular Pharmacokinetics After a Single Drop Instillation of T1225 0.5, 1, 1.5% in 91 Healthy Volunteers...

Eye InfectionsBacterial

To evaluate azithromycin tear concentrations after instillation of one drop of one of the three T1225 concentrations (0.5%, 1% and 1.5%) and to evaluate the ocular safety.

Completed13 enrollment criteria

Mycotic Ulcer Treatment Trial I

Corneal UlcerEye Infections1 more

The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.

Completed20 enrollment criteria

The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo...

Corneal UlcerEye Infections1 more

The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.

Completed21 enrollment criteria
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