Solanezumab Safety Study in Japanese Patients With Alzheimer's Disease
Alzheimer's DiseaseThe purpose of this study is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple dosing Solanezumab in subjects with mild-to-moderate AD in Japanese population.
Study Evaluating The Potential Interaction Between Verapamil Immediate Release And SAM-531 When...
Alzheimer DiseaseThe purpose of this study is to evaluate the effects of multiple doses of verapamil on the plasma concentration of a single dose of SAM-531 in healthy young adult subjects and to assess the safety and tolerability of co-administration of SAM-531 and verapamil.
Tolerability and Safety of Subcutaneous Administration of AFFITOPE AD02 in Mild to Moderate Alzheimer's...
Alzheimer's DiseaseThe purpose of this study is to assess the tolerability and safety of repeated subcutaneous injection of a single dose of AFFITOPE AD02 in patients with mild to moderate Alzheimer's Disease.
Study of SB-742457 or Donepezil Versus Placebo in Subjects With Mild-to-moderate Alzheimer's Disease...
Alzheimer's DiseaseThe study is designed to investigate the efficacy, safety and tolerability of SB-742457 versus placebo in subjects with mild-to-moderate Alzheimer's disease. SB-742457 is an experimental treatment which increases the levels of certain chemicals in the brain that are often decreased in patients with Alzheimer's disease.
Bridging Study With GSK239512 In Patients With Mild To Moderate Alzheimer's Disease
Alzheimer's DiseaseThis is a safety and tolerability study to investigate the effect of GSK239512 on mild to moderate Alzheimers disease patients. The dose of GSK239512 will be titrated to reach the most well tolerated dose in the patients.
The Efficacy of Galantamine Treatment on Attention in Patients With Alzheimer's Disease
Alzheimer's DiseaseThis study will examine whether the administration of galantamine is effective for improvement of attention and more effective for patients with serious disturbance of attention by administering galantamine to patients with Alzheimer's dementia and performing an attention test on baseline, week 4 and 12.
Hormone and Information Processing Study
Mild Cognitive ImpairmentAlzheimer's DiseaseThe purpose of this study is to examine the effects of testosterone (T) replacement on changes in thinking and memory, as well as mood in older men with mild cognitive impairment (MCI) and low T levels. The study will also examine whether taking testosterone has effects on biological markers related to Alzheimer's disease.
Proof of Concept Study of Cognitive Improvement in Patients With Alzheimer's Disease
Alzheimer DiseaseThe purpose of this study is to demonstrate that AZD3480 improves cognition in patients with mild or moderate Alzheimer's disease, to assess the safety and tolerability of ZAD3480 and to define the optimal dose(s) to be used in future trials.
Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy
Alzheimer's DiseaseThe study will include a preliminary pharmacokinetics (PK) / safety / tolerability evaluation in healthy elderly subjects followed by the Receptor Occupancy (RO) evaluations in healthy elderly subjects and in Alzheimer's Disease (AD) subjects.
Study Evaluating the Effect of Lecozotan SR on the QTc Interval
Alzheimer DiseaseHealthyThis is a randomized, double-blind, placebo- and moxifloxacin (open-label)-controlled, 4-period crossover study.