Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye
Fuch's DystrophyCorneal Disorders1 moreThe purpose of this research is to evaluate the optical coherence tomography (OCT), to image diseases of the eye. OCT may be useful for the early diagnosis and monitoring of a variety of diseases involving the eye, such as Fuch's Dystrophy (type of eye disease) and retinal damage (eye diseases in the back of the eye) due to diabetes.
Trial of Netarsudil for Acceleration of Corneal Endothelial Restoration
Fuchs' Endothelial DystrophySubjects with Fuchs dystrophy will be randomized to use either netarsudil or placebo eye drops to determine if the use of netarsudil accelerates migration of host peripheral corneal endothelial cells to restore the central endothelial cell layer.
OCT-guided DSAEK Graft Shaping and Smoothing
Fuchs' Endothelial DystrophyThe primary goal of this study is to determine if excimer laser smoothing of the cornea before Descemet's stripping automated endothelial keratoplasty (DSAEK)improves postoperative Best Spectacle Corrected Visual Acuity (BSCVA).
A Phase 2 Study Evaluating the Safety and Efficacy of Netarsudil Ophthalmic Solution in Patients...
Corneal EdemaTwo different dosing regimens (QD and BID) of netarsudil will be studied to evaluate their efficacy in reducing or resolving corneal edema in subjects with FCD.
Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty
Fuchs' Endothelial DystrophyThis randomized controlled trial evaluates the efficacy and safety of postoperative supine head positioning on graft attachment after Descemet membrane endothelial keratoplasty in patients with Fuchs' endothelial corneal dystrophy (FECD).
DMEK Versus DSAEK Study
Fuchs' Endothelial DystrophyThe purpose of this study is to determine whether corneal transplantation by Descemet Membrane Endothelial Keratoplasty more favourable and cost-effective is compared to Descemet Stripping Automated Endothelial Keratoplasty for Fuchs Endothelium Corneal Dystrophy.
Study to Investigate the Safety and Efficacy of K-321 in Patients With Fuchs Endothelial Corneal...
Fuchs' Endothelial Corneal DystrophyThe objective of this study is to investigate the effect of K-321 in patients with Fuchs endothelial corneal dystrophy (FECD) after descemetorhexis.
A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema...
Fuchs DystrophyCorneal EdemaThe objectives of this study are to compare the visual and refractive outcomes of deep lamellar endothelial keratoplasty (DLEK) with penetrating keratoplasty as treatment for certain cases of corneal edema due to endothelial decompensation. Additionally, data will be collected to compare corneal shape, corneal thickness, endothelial cell density, keratocyte density, corneal sensitivity, light scatter, and subjective visual function between the two procedures.
Eye Drops for Early Morning-Associated Corneal Swelling of the Cornea
Fuchs' Endothelial DystrophyThis study evaluates the efficacy of hyperosmolar eye drops on early morning edema of the cornea in patients with Fuchs' endothelial corneal dystrophy (FECD). Each participant will receive hyperosmolar eye drops in one eye and lubricating eye drops in the fellow eye.
Fuchs' Torsional Phaco Study
Fuchs' Endothelial DystrophyPhacoemulsificationThe primary objective is to compare the effect of torsional phacoemulsification and longitudinal phacoemulsification on central and peripheral corneal thickness/volume after cataract surgery in patients with Fuchs' endothelial dystrophy.