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Active clinical trials for "Neoplasms, Glandular and Epithelial"

Results 31-40 of 56

First in Human Study of NG-350A (an Oncolytic Adenoviral Vector Which Expresses an Anti-CD40 Antibody)...

Metastatic CancerEpithelial Tumor

This study will evaluate the safety, tolerability and preliminary efficacy and also pharmacokinetics, immunogenicity and other pharmacodynamic effects to elucidate the mechanism of action of NG-350A, either alone or in combination with a check point inhibitor, in patients with advanced or metastatic epithelial tumours.

Completed54 enrollment criteria

Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial...

Colorectal CancerSquamous Cell Carcinoma of the Head and Neck1 more

This is a Phase I multicenter, open label, nonrandomized study of enadenotucirev administered in combination with nivolumab in subjects with metastatic or advanced epithelial tumors (with focus on CRC, SCCHN, escalation phase), not responding to standard therapy.

Completed40 enrollment criteria

A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor

Thymic Epithelial Tumors

This is a Phase II single center, open-label, single arm study in patients with advanced thymic epithelial tumors after failure of cisplatin-based combination chemotherapy. Patients will be treated with Pembrolizumab 200 mg every 3 weeks.

Completed28 enrollment criteria

A Phase I Study of Belinostat in Combination With Cisplatin and Etoposide in Adults With Small Cell...

Carcinoma NeuroendocrineSmall Cell Lung Carcinoma1 more

BACKGROUND: The histone deacetylase (HDAC) inhibitors are a novel class of anticancer agent. These agents lead to the increased acetylation of both histone and non-histone proteins, which leads to rapid cell death in many tumor models. It is thought that the cell death observed with this class of agents may be mediated, in part, through the selective acetylation of histone proteins resulting in increased expression of specific genes. For solid tumors in general, cell death in preclinical models has not translated to activity in patients. For this reason, studies increasingly have combined chemotherapy with HDAC inhibitors to achieve additive and potentially synergistic effects on cancer cells. This protocol will study a continuous infusion of the HDAC inhibitor belinostat in combination with cisplatin and etoposide for patients with advanced cancer. OBJECTIVES: To determine a safe and tolerable phase 2 dose for the combination of belinostat with cisplatin and etoposide. Evaluate molecular markers of HDAC inhibition. ELIGIBILITY: The protocol will be open to all patients with recurrent or advanced cancer (small-cell lung cancer and other advanced cancers) for whom standard therapy offers no curative potential. Age greater than or equal to 18 years ECOG Performance Status 0-2 DESIGN: The study will begin with belinostat 400 mg/m (2)/24h administered by continuous IV infusion on days 1 and 2, cisplatin at 80 mg/m (2) IV on day 2, and etoposide at 100 mg/m (2) IV daily times 3 on days 2 - 4. Dose escalation of belinostat will follow according to traditional 3 patient cohorts. Treatment schedule and dose escalation schemata.

Completed29 enrollment criteria

Cardiac Safety Study of Entinostat in Men and Women With Advanced Solid Tumors

NeoplasmsNeoplasms15 more

The purpose of this study is to evaluate the effect of entinostat on heart rate and other electrocardiogram (ECG) parameters. This study will also evaluate the safety and tolerability of entinostat, as well as pharmacokinetic and pharmacodynamic parameters.

Completed14 enrollment criteria

A Phase 2 Feasibility Study of Abraxane and Carboplatin in Epithelial Neoplasms of the Uterus

Endometrial Cancer

The purpose of this study is to evaluate the safety of treatment with carboplatin and Abraxane in this patient population and determine the nature and degree of toxicities following treatment. The single stage open label Phase II feasibility study is designed to estimate the proportion of patients who can tolerate the proposed regimen for 6 cycles with no more than two dose level reductions.

Completed19 enrollment criteria

A Study of the Safety and Pharmacokinetics (PK) of MEHD7945A in Participants With Locally Advanced...

Epithelial TumorsMalignant

This is a Phase I, multicenter, open-label study of MEHD7945A in participants with incurable, locally advanced, or metastatic epithelial malignancies that have progressed despite standard therapy or for which no standard therapy exists. The study will be conducted in two stages: a dose escalation stage and an expansion stage. The dose-escalation stage is designed to evaluate the safety, tolerability, and PK of MEHD7945A administered (at five dose levels from 1 to 30 milligrams per kilogram [mg/kg]) every 2 week (Q2W). An expansion stage will be initiated after establishment of maximum tolerated dose (MTD) in dose escalation stage. Participants with refractory or recurrent metastatic colorectal cancer (CRC), non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and pancreatic cancer will be enrolled in an expansion stage to better characterize the safety, tolerability, PK and preliminary assessment of the anti-tumor activity of MEHD7945A.

Completed21 enrollment criteria

Continuation Study of Entinostat in Combination With Pembrolizumab in Patients With Advanced Solid...

NeoplasmsNeoplasms14 more

The objectives of this study are to explore different dosing levels and schedules of entinostat in combination with pembrolizumab in patients with advanced solid tumors, in terms of safety, tolerability, pharmacokinetics (PK), impact on immune correlatives, and efficacy

Completed5 enrollment criteria

Study of the Safety of VB6-845 in Patients With Advanced Solid Tumours of Epithelial Origin

NeoplasmsGlandular and Epithelial

The purpose of this study is to determine the maximum tolerated dose (MTD) of VB6-845 and to evaluate the safety and tolerability of VB6-845 when administered as a monotherapy IV infusion to patients with advanced solid tumour of epithelial origin.

Terminated18 enrollment criteria

BowelScope: Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities

Colorectal NeoplasmsColonic Polyp14 more

This study aims to assess the effect, if any, on the adenoma detection rate of BowelScope bowel cancer screening flexible sigmoidoscopies by using the Endocuff Vision device.

Completed12 enrollment criteria
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