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Active clinical trials for "Celiac Disease"

Results 81-90 of 264

Latiglutenase as a Treatment for Celiac Disease

Celiac Disease

Single Center, Randomized, Double-Blind, Placebo Controlled, Gluten Challenge Trial in Patients with Well-Controlled Celiac Disease

Completed22 enrollment criteria

Study of the Safety, Pharmacodynamics, Efficacy, and PK of TIMP-GLIA in Subjects With Celiac Disease...

Celiac Disease

Subjects enrolled in this study will be evaluated for immune responses and histological changes in the small bowel following 2 doses of TIMP-GLIA or placebo and a 14-day oral gluten challenge.

Completed17 enrollment criteria

Safety and Systemic Exposure Study of BL-7010 in Well-Controlled Celiac Patients.

Celiac Disease

The purpose of this study is to evaluate the safety of different amounts of BL-7010 in single oral administration and in repeated oral administration to well-controlled celiac patients. Another purpose is to evaluate if BL-7010 is absorbed by the body or not.

Completed17 enrollment criteria

Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome

DiarrheaDiarrhea Predominant Irritable Bowel Syndrome

The specific hypotheses are: Gluten supplementation for four weeks increases small intestinal permeability and accelerates colonic transit in patients with irritable bowel syndrome with diarrhea (IBS-D) or functional diarrhea (FD) who are HLA-DQ2 positive.

Completed13 enrollment criteria

Antibody Treatment for Advanced Celiac Disease

Celiac DiseaseCeliac Sprue2 more

Background: - Celiac disease is a condition where the immune system attacks the cells of the small intestine. The intestine becomes inflamed and cannot digest food properly. The disease most often causes a reaction to foods that contain gluten. Most people can treat celiac disease with a gluten-free diet. However, some people have digestion problems even on a gluten-free diet. Researchers want to try a new antibody therapy for celiac disease. The treatment may block the immune reaction that causes the disease. They will test this antibody in people who have celiac disease that has not responded to a gluten-free diet. Objectives: - To see if antibody therapy is a safe and effective treatment for celiac disease that has not responded to standard treatments. Eligibility: - Individuals at least 18 years of age who have been on a gluten-free diet for 6 to 12 months but still have symptoms of celiac disease. Design: Participants will be screened with a physical exam and medical history. Blood samples will be collected. These samples will help determine if the specific antibody treatment is likely to work. Before the start of the study, participants will have a biopsy of the small intestine. Participants will receive three doses of the study antibody as injections. These doses will be given 3 weeks apart. Treatment will be monitored with blood tests and heart function tests. Participants will also have a second small intestine biopsy within a week after the last dose of the antibody.

Completed32 enrollment criteria

Safety Study of Nexvax2 in Subjects With Coeliac Disease

Coeliac DiseaseCeliac Disease

The main purpose of this study is to determine the safety of weekly injections of Nexvax2 given for three weeks to patients with coeliac disease who have been on a gluten-free diet. The second purpose of this study is to compare the immune response over the three week study period in coeliac disease patients given Nexvax2 compared to those given saline.

Completed28 enrollment criteria

Study of Enzyme Supplements to Treat Celiac Disease

Celiac DiseaseDermatitis Herpetiformis

The purpose of this study is to examine whether a cocktail of two common food-grade enzyme supplements leads to decrease of serum activity markers in celiac disease patients insufficiently treated by previous gluten exclusion.

Completed8 enrollment criteria

Study to Assess the Efficacy of Larazotide Acetate for the Treatment of Celiac Disease

Celiac Disease

This study was conducted to evaluate the efficacy of multiple doses of larazotide acetate in preventing intestinal permeability changes induced by a 6- week gluten challenge in subjects with celiac disease.

Completed7 enrollment criteria

Safety and Efficacy of ALV003 for the Treatment of Celiac Disease

Celiac Disease

A phase 2a study to evaluate the safety and efficacy of ALV003 to treat celiac disease.

Completed14 enrollment criteria

Safety and Tolerability Study of Larazotide Acetate in Celiac Disease Subjects

Celiac Disease

This study was run to determine the safety, tolerance, and efficacy of multiple doses of larazotide acetate in subjects with celiac disease following a gluten challenge.

Completed7 enrollment criteria
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