Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function...
Congestive Heart Failure ChronicThis is a randomized, double-blind, placebo-controlled trial evaluating the effect of resveratrol on metabolic and skeletal muscle function. Patients will be randomized and allocated to either resveratrol or placebo, for 8 weeks with a 2-week run-in period before the intervention period (to ensure they are not on any nutritional supplement that contains resveratrol).
Zero Sodium Peritoneal Dialysate Protocol Pilot Study
Potential Applications for Heart FailureVolume OverloadThe following pilot study will be undertaken to determine the effects of use of a zero-sodium peritoneal dialysate solution (10% dextrose in sterile water) on sodium removal as compared to a standard peritoneal dialysis solution.
Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment...
HyperkalemiaThe purpose of this study is to assess the effects of patiromer compared with placebo on serum K+ in HF patients.
Study for Breathing Interventions in Congestive Heart Failure
Congestive Heart FailureSlow breathing may reduce stress. Adults with congestive heart failure have higher stress than the general population. This study will examine if using slow breathing is feasible among adults with heart failure.
SPECT-based Prediction and Evaluation of CRT Efficacy in CHF
Chronic Heart FailureThis study evaluates the state of the cardiac sympathetic activity and the severity of ventricular dyssynchrony in chronic heart failure patients and assesses the capabilities of radionuclide indication methods in determining the prognosis and evaluating the results of cardiac resynchronization therapy in chronic heart failure patients.
Study of Sacubitril/ValsarTan on MyocardIal OxygenatioN and Fibrosis in Heart Failure With Preserved...
Heart Failure With Preserved Ejection FractionTo assess the effect of ARNI on myocardial deoxygenation at stress and myocardial fibrosis, and correlate this to changes in myocardial systolic and diastolic function in HFpEF patients.
AC6 Gene Transfer in Patients With Reduced Left Ventricular Ejection Fraction Heart Failure
Heart FailureTo determine the safety and efficacy of an intracoronary injection of adenovirus 5 encoding human adenylyl cyclase 6 (RT-100) in patients with heart failure with reduced left ventricular ejection fraction (HFrEF) in a Phase 3 clinical trial.
Sacubitril-valsartan Versus Usual Anti-hypertensives in LVAD
Congestive Heart FailureHypertensionThis pilot, feasibility study evaluates the efficacy of sacubitril-valsartan (Entresto) versus usual anti-hypertensive medications in patients with left ventricular assist devices (LVAD). It also measures diurnal blood pressure variations in the context of continuous flow physiology.
Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery
Cardiac DiseaseCardiac Failure3 moreThe aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery
Efficacy and Safety of TRC041266 in Patients With Heart Failure, LVEF ≥40%, Diastolic Dysfunction...
Chronic Stable Heart FailureThis study will be conducted as a randomized, multi-centre, double-blind, parallel-group, placebo-controlled study in patients receiving SoC therapy. Eligible participants will be randomized in a ratio of 1:1 to receive either test product, TRC041266 1500 mg or matching placebo twice daily for 48 weeks