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Active clinical trials for "Hypercholesterolemia"

Results 881-890 of 1126

Effects of Vitamin D on Lipids

HypercholesterolemiaVitamin D Deficiency

The purpose of this study is to examine whether oral vitamin D supplementation in people with inadequate vitamin D concentrations will lower LDL-cholesterol and total cholesterol concentrations.

Completed10 enrollment criteria

Effects of Ezetimibe on the Absorption of Oxidized Cholesterol

Hypercholesterolemia

The purpose of this study is to test the effects of Zetia™ (ezetimibe) 10 milligrams (mg) on the absorption of oxysterol into the blood following a meal containing oxysterol.

Completed39 enrollment criteria

A Study Comparing the Mechanisms of Action of Lifibrol and Pravastatin

HypercholesterolemiaHyperlipoproteinemia

Lifibrol is a new lipid-lowering drug which lowers cholesterol to an extent in the order of magnitude of the statins. The mechanism of action of this compound is different from the one of statins but remains unknown. The current study will investigate the mechanism of action using stable-isotope turnover methods. The study will be done in healthy male volunteers.

Completed11 enrollment criteria

Can Cholesterol Lowering Drugs Influence Circulating Omega-3 Fatty Acid Levels

HypercholesterolemiaHyperlipidemia

The objective of this study is to determine if the administration of a cholesterol lowering drug like ezetimibe will reduce circulating omega-3 fatty acid (ALA) levels in patients with heart disease and hypercholesterolemia. The investigators hypothesize that their data will discover that patients receiving ezetimibe require additional dietary supplementation with omega-3 supplements to insure that these beneficial fatty acids are available to these patients.

Completed6 enrollment criteria

Alternative Options to Minimize Niacin-Induced Flushing

HypercholesterolemiaFlushing

Niacin (Vitamin B3) is known to effectively and safely treat hypercholesterolemia. However, use of niacin is limited due to incidents of flushing which limits its acceptability. Some information suggests that applesauce can reduce the incidence and severity of flushing. The apple pectin in particular is thought to be the ingredient that affects this reaction. To determine if the apple pectin does affect flushing from niacin, the investigators will study the affects of isolated apple pectin in pill form. The investigators plan on recruiting 100 patients, and giving them 1000 mg of Niacin to induce flushing. Patients will be divided into 4 treatment groups and receive either pectin, aspirin, a combination of both, or placebo. Incidents and severity of flushing will be monitored for up to 6 hours post Niacin ingestion.

Completed18 enrollment criteria

Improving the Quality of Patient Care by Using a Clinical Expert System.

HypertensionDiabetes3 more

Aim: To investigate the quality of history taking by physician and computer-based system. Patients: 100 inpatients presenting at the RBK for the first time and treated in the departments of nephrology and cardiology. Methods: The information obtained by the computer based system is compared with the information acquired by conventional history taking. Study endpoint is the comparison of historical data organized according to the elements in a standard medical history on a patient-by-patient basis. Study procedure History taking is performed by physicians according to the guidelines of the RBK. Within 2 days thereafter the patient is interviewed with help of the CLEOS system with the support of a study nurse.

Completed2 enrollment criteria

A Community Pharmacist-led Intervention to Improve Adherence to Lipid-lowering Treatment

Hypercholesterolemia

The objective of the study is to test the effectiveness of a community pharmacist-led intervention to increase adherence to lipid lowering treatment.

Completed6 enrollment criteria

A Patient-Spouse Intervention for Self-Managing High Cholesterol

Hypercholesterolemia

We examined the effect of a patient-spouse intervention to lower LDL-C by increasing patient treatment adherence. A randomized controlled trial compared a one-year, telephone-based patient-spouse intervention to usual care. The primary outcome was LDL-C measured three times (baseline, 6 months, 11 months); secondary outcomes were adherence to medication, diet, and exercise, also assessed at baseline, 6 months, and 11 months.

Completed11 enrollment criteria

HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Homozygous Familial HypercholesterolemiaHoFH

Assess the effect on coronary atheroma of serial infusions of autologous selectively delipidated HDL/preβ enriched plasma following use of HDL Therapeutics PDS-2™ System

Unknown status10 enrollment criteria

Safety and Efficacy of CVI-LM001 in Patients With Hypercholesterolemia

Hyperlipidemia

The purpose of this study is to determine if CVI-LM001 is effective and safe versus placebo in drug-naive subjects with elevated LDL cholesterol. There will be 4 groups receiving 100mg, 200mg, 300 mg and placebo treatment for 12 weeks respectively.

Unknown status8 enrollment criteria
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