Study of DHT-Gel to Treat the Symptoms of Low Testosterone in Men 55-80
HypogonadismLate Onset Hypogonadism1 moreThe purpose of this study is to evaluate whether DHT-Gel, when applied daily to the skin, can relieve the symptoms of low testosterone in men aged 55-80. These symptoms include reduced muscle strength, increase fat mass, low libido, feeling blue or moody
Pilot Pharmacokinetic Study of Oral Testosterone Ester Formulations in Hypogonadal Men
HypogonadismDetermine the serum pharmacokinetic profile for two oral formulations of T-esters (one TE and one TU) administered once -(QD) and twice-daily (BID) to hypogonadal men.
Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone...
Primary HypogonadismHypogonadotropic HypogonadismBioequivalence study comparing the rate and extent of testosterone absorption for a test formulation versus the reference product.
A Study of Ejaculatory Dysfunction in Men With Low Testosterone Levels
Ejaculatory DysfunctionHypogonadismThe purpose of this study is to see if testosterone solution 2% can impact symptoms of ejaculatory dysfunction in men with low testosterone.
Time to Eugonadal Range, Time to Steady State and Drying Time
Male HypogonadismThis is a multicenter, open-label, single arm trial to evaluate the time to eugonadal testosterone range after initial testosterone gel 2% application, time to steady state after after initiation of testosterone gel 2%, and drying time after application of testosterone gel 2%.
Efficacy of an Intranasal Testosterone Product
HypogonadismThis clinical trial will compare the pharmacokinetic profile of testosterone after repeated intranasal administration of TBS-1 of different strengths in subjects with hypogonadism
A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic...
HypogonadismHypogonadotropic HypogonadismThis study will assess if corifollitropin alfa (MK-8962), when administered in combination with human chorionic gonadotropin (hCG), will increase testicular volume in men with HH who remain azoospermic after treatment with hCG alone. Hypothesis: The lower limit of the 95% confidence interval for the geometric mean increase in testicular volume from Day 1 to Week 52 is greater than one.
Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure
HypogonadismTo further characterize the transfer potential of marketed testosterone gel and new 1.62% formulation.
The Effect of Testosterone on Mood and Quality of Life
Gonadal DisordersDepressive Disorder1 moreWe hypothesize that testosterone replacement will improve mood and quality of life in older men with low testosterone and mild depression. Study subjects will receive either testosterone gel or a placebo (inactive) gel for 12 weeks. Neither the subject or the investigator will know whether they are receiving placebo or testosterone gel. At the end of the initial 12 week period, all subjects will receive testosterone gel for 12 more weeks. Mood and quality of life measures will be obtained at baseline, at the end of the double-blind phase and at the end of the extension phase (when all subjects receive testosterone.)
MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism
Prostate CancerMetabolic Syndrome2 moreThe purpose of this study is to investigate if androgen deprivation therapy in men with prostate cancer increases hepatic fat content and changes visceral/subcutaneous fat distribution.