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Active clinical trials for "Intervertebral Disc Degeneration"

Results 291-300 of 415

Autologous Adipose Derived Stem Cell Therapy for Intervertebral Disc Degeneration

Low Back Pain

Subject: 10 patients : Chronic low back pain patients with lumbar intervertebral disc degeneration Investigational Product : Autologous adipose derived mesenchymal stem cells plus hyaluronic acid derivatives (Tissuefill) Time frame 1 year

Unknown status20 enrollment criteria

Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion

StenosisHerniated Nucleus Pulposus5 more

Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit. This occurs with traversal of the psoas muscle or direct injury to lumbosacral plexus or sympathetic ganglion. While often temporary, it can cause hip flexor weakness, thigh numbness, or pain. Several studies have demonstrated reduced patient reported pain scores following steroid administration, particularly in the early postoperative period. However, few studies have investigated the efficacy of intraoperative local injection of corticosteroid in reducing the incidence and duration of postoperative pain or neurologic injury for XLIF patients.

Withdrawn7 enrollment criteria

The Efficacy of Continuous Cold-Therapy on Postoperative Pain and Narcotics Use Following Spinal...

RadiculopathyCentral Spinal Stenosis5 more

Patient outcomes and satisfaction are an ever-increasing priority in surgical specialties. Cryotherapy has been utilized following spine surgery as an adjunct therapy to reduce postoperative inflammation and improve patient outcomes. However, limited studies have investigated the effect of cryotherapy on postoperative pain and narcotics use. Fountas et al. performed a randomized controlled trial to assess the impact of postoperative cryotherapy following single-level lumbar microdiscectomy. The authors reported patients receiving cryotherapy required significantly less pain medication (0.058 mg/kg/hr versus 0.067 mg/kg/hr, p<0.001) and had shorter hospital stays (1.71 days versus 2.65 days, p<0.001) as compared to the control group. In another randomized trial of single-level lumbar discectomy patients, Murata et al. demonstrated cryotherapy to have no significant effect on VAS inpatient pain scores or postoperative blood loss.

Withdrawn6 enrollment criteria

Efficacy and Safety of K-rod Dynamic Stabilization System in the Repair of Lumbar Degenerative Diseases...

Intervertebral Disk Degeneration

To conduct a prospective, single-center, self-controlled, clinical trial to verify the efficacy and safety of K-Rod dynamic stability system in the repair of lumbar degenerative diseases following 2 years follow-up, aiming to provide references for clinical treatment of lumbar degenerative diseases.

Unknown status8 enrollment criteria

Study of Nucel for One and Two Level Lumbar Interbody Fusion

Degenerative Disc DiseaseSpondylolisthesis1 more

The study is a prospective non-randomized multi-center feasibility clinical trial to establish the safety and efficacy of the Nucel® allograft tissue for use in lumbar interbody fusion procedures.

Unknown status16 enrollment criteria

Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar...

Intervertebral Disc DegenerationLumbar Spinal Stenosis

The purpose of this study is to determine the effectiveness of minimally invasive surgical technique over the traditional open surgical procedure in patients with degenerative lumbar stenosis

Withdrawn10 enrollment criteria

Safety and Efficacy Study of Matrilin-3 Pretreated Autologous Adipose Derived Mesenchymal Stem Cells...

Patients With Chronic Low Back Pain Due to Degenerative Lumbar Disc

To investigate the safety and efficacy of autologous adipose-derived mesenchymal stem cell spheroids pretreated with matrillin-3 in chronic low back pain patients with lumbar intervertebral disc degeneration.

Unknown status24 enrollment criteria

Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP...

Intervertebral Disc DegenerationChronic Low-back Pain

ACTIVE is a phase II B efficacy monocenter, prospective, randomized, controlled double blinded trial, in which intra-discal autologous adult BM-MSC therapy will be compared with sham treated controls. This trial will evaluate the efficacy of intradiscal injection of autologous BM-MSCs in workers affected by chronic low back pain (LBP) unresponsive to conventional therapy. The efficacy will be evaluated 12 months after the treatment in terms of pain relief (VAS, Visual Analog Scale), functionality (ODI, Oswestry Disability Index), quality of life (SF36, Short Form - 36) and work ability index (WAI).

Unknown status37 enrollment criteria

Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy

Degenerative Disc DiseaseChronic Low-back Pain

This study will be a prospective, open-label, multi-center study that will collect safety data for the minimally invasive PerQdisc Nucleus Replacement Device deployed to reduce chronic low back pain.

Unknown status32 enrollment criteria

Allogeinic Bone Paste

Cervical FusionCervical Disc Degeneration1 more

This is a prospective, single arm, single center clinical study to evaluate efficacy and safety of a Supercritical CO2 viral-inactivated allogenic bone paste in cervical interbody fusion. Patient eligible for 1- or 2-level ACDF (Anterior Cervical Discectomy and Fusion) combined with bone graft after failure of well-conducted medical treatment will be screened for the study.

Unknown status19 enrollment criteria
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