Stone Centre Urine and Serum Bank
Kidney StonesPurpose: The purpose of the Stone Centre Serum and Urine Bank is to provide researchers with large numbers of serum and urine samples from kidney stone patients and controls for study of stone disease detection and treatment, and will take into account different genetic backgrounds, ages, and other patient factors to provide a broad sample size for the study of stone disease The Serum and Urine Bank will undoubtedly be an invaluable tool in the quest to understanding urinary stone disease. Objective: The objective of this research is to identify protein species or other compounds responsible for or contributing to kidney stone initiation and propagation.
Efficacy and Safety of Using MPC-5971 in Subjects Undergoing Shock Wave Lithotripsy
NephrolithiasisThe purpose of this study is to evaluate the efficacy of MP-5971 in facilitating stone passage after Shock Wave Lithotripsy treatment.
Evaluation of Infection in Obstructing Urolithiasis
Kidney StoneKidney Calculi3 moreObstructing urolithiasis can be life-threatening in the setting of urinary tract infection. The purpose of this study is to identify and validate risk factors and markers for the presence of infection and development of sepsis among patients with obstructing urolithiasis.
The Effect of Vitamin D Repletion on Kidney Stone Risk
CalculiExamine the effect of nutritional vitamin D repletion on urinary calcium excretion and kidney stone burden in calcium kidney stone formers
Trial Comparing the Effect of a Paravertebral Block on Pain Post Percutaneous Nephrolithotomy
NephrolithiasisThis is a randomized control trial (meaning the selection is random as when flipping a coin) to assess the benefit of paravertebral blockade (PVB) in Percutaneous nephrolithotomy/nephrolithotripsy (PCNL) surgery.
Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria
Dent's DiseaseNephrolithiasisIntrarenal calcifications (nephrocalcinosis) is present in Dent's disease and likely contribute to progression toward renal failure. In order to prevent this complication it is usually proposed to treat affected patients during childhood with high doses of thiazides.
Clinical Evaluation of BackStop in Patients Undergoing Ureteroscopic Lithotripsy
Kidney StonesThe purpose of this clinical study is to evaluate BackStop, a polymer-based device that is intended to be used during ureteroscopic lithotripsy to prevent retrograde stone migration.
The Effect of Ureteric Stent Tethers on Patient Symptoms and Urinary Infection
Kidney StoneRESEARCH QUESTION Do ureteric stents with tethers, left in-situ for 1-2 weeks, increase the rate of stent bacterial colonization, urinary bacterial colonization and stent related lower urinary tract symptoms compared to stents without tethers? HYPOTHESIS We hypothesize that ureteral double-J stents with tethers increase the rate of stent bacterial colonization, but do not increase the rate of urinary bacterial colonization or stent related lower urinary tract symptoms compared to stents without tethers when left in-situ for 1-2 weeks.
Obesity and Endogenous Oxalate Synthesis
ObesityKidney StoneThe goal of this proposal is to determine the contribution and significance of obesity to urinary oxalate excretion and thus calcium oxalate kidney stone disease. Successful completion of the study will provide insight into the link between obesity and kidney stone disease and should identify future strategies to treat this disease.
Use of Antiretropulsion Device in Laser Lithotripsy
Kidney StonesThe objectives of this post-market evaluation are to assess the capacity of the procedure to be completed with use of only a semi-rigid ureteroscope, without requiring use of a flexible ureteroscope to compare the rate of retropulsion and the time required to complete the lithotripsy in patients in which the Accordion device is used in contrast to when such a device is not employed.