Rehabilitation in Parkinson Disease Cyclone in Life
Parkinson DiseasePhysical DisabilityComparison of two rehabilitation protocols in patients with Parkinson's disease and, therefore, identification of innovative rehabilitation protocols of proven and validated efficacy, through which it is possible to achieve: Improved joint function and gait pattern Reduction of the risk of falling or reduction of energy expenditure during physiological gait Evaluation of the increase in maximal effort tolerance · Improved cognitive performances Evaluation of the impact on the quality of life of the patient and family members Identification of morpho-functional markers predictive of clinical and rehabilitative out-come through neuroimaging study.
An Observational Study of Patients Living With Chronic Neurological Diseases
Neurological Diseases or ConditionsDementia of Alzheimer Type4 moreTARGET-NEURO is an observational research study to conduct a comprehensive review of outcomes for patients living with chronic neurological diseases: Alzheimer's disease and related dementia (ADRD), mild cognitive impairment (MCI), Parkinson's disease (PD), and multiple sclerosis (MS).
Comparative Effects of Cognitive and Motor Dual Task Training on Balance and Quality Of Life in...
Parkinson DiseaseBalance; Distorted1 moreTo Compare Effects of Cognitive and Motor Dual Task Training on Balance and Quality Of Life in Parkinson's Patients
Study to Evaluate the Effects of Cytochrome P450 (CYP) 3A4 Inducer Carbamazepine on Tavapadon Pharmacokinetics...
Parkinson DiseaseThe primary purpose of this study is to evaluate the effect of carbamazepine, a strong CYP3A4 inducer, on the steady-state pharmacokinetics (PK) of tavapadon in healthy adult participants.
Model-based Cueing-as-needed for Walking in Parkinson's Disease
Parkinson DiseaseWalking3 moreCorrecting of the lack of regularity in steps is a key component of gait rehabilitation in Parkinson's disease. The proposal is to introduce adaptive spatial auditory cueing (ASAC) based on verbal instruction "lengthen the step" automatically delivered when the stride length decreased below a predetermined threshold. The present study compared the effect of usual rhythmic auditory cueing versus ASAC used during a walking training in Parkinson's disease.
Immersive Virtual Reality for the Non-pharmacological Management of Parkinson's Disease
Parkinson DiseaseThe goal of this clinical trial is to evaluate the feasibility, safety and efficacy of an immersive virtual reality (IVR) exergaming using a head-mounted display in Parkinson's disease symptomatic control. This is a parallel-group, single-blinded, randomized controlled trial. The intervention group perform 12 weeks of physiotherapy and IVR, whereas the control group have 6 weeks of physiotherapy only, followed by 6 weeks of physiotherapy and IVR. The primary outcome is the symptomatic effect of the intervention as measured by the change from baseline in Time Up and Go (TUG) test with cognitive dual-task (TUG cognitive).
Cycling Dual-task in Parkinson's Disease
Parkinson DiseaseTaking into account the process of functional and cognitive evolution that patients with Parkinson's disease experience throughout the evolution of the pathology, the objective of this study is to evaluate the effect of a dual-task program combining cognitive tasks and forced cycling on the functional and cognitive capacity of these patients.
Incentive Spirometer and Inspiratory Muscle Trainer
Parkinson DiseasePatients suffering from parkinsonism have respiratory function abnormalities. This study compared the effects of incentive spirometer and inspiratory muscle trainer on pulmonary functions in patients with parkinsonism.
DTI in Evaluation of Parkinsons Disease
Mri in ParkinsonsThe aim of this study is to evaluate the role of different magnetic resonance sequences in demonstration of microstructural abnormalities in Parkinson's disease.
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease
Parkinson DiseaseEffect of DrugIn recent years, mitochondrial dysfunction and oxidative stress have been implicated in PD pathophysiology. Intermittent hypoxia therapy (IHT) is an upcoming treatment used by elite athletes as well as fragile individuals in clinical settings that works by improving exercise tolerance, neuroplasticity and inducing hypoxic preconditioning (HPC). HPC might improve the oxidative stress response in PD on the long-term. In addition, preclinical evidence suggests beneficial short-term effects such as influence on dopamine and noradrenalin release. Anecdotal evidence indeed suggests that visiting high-altitude areas improves PD symptoms and it is hypothesized that this effect results from decreased oxygen pressure at high altitudes. The safety and feasibility of (intermittent) hypoxia therapy on PD symptoms will be assessed in an exploratory phase I randomized-controlled trial.