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Active clinical trials for "Bone Diseases, Metabolic"

Results 91-100 of 355

Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS)

ScoliosisBone Diseases1 more

This is a prospective randomized controlled trial investigating the effect of vibration therapy on bone mineral density (BMD) and bone quality in AIS subjects suffering from osteopenia (low bone mass).

Completed11 enrollment criteria

An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With...

Osteopenia

The purpose of this study is to assess the safety, tolerability, and potential immune response of AMG 167 following multiple subcutaneous (SC, injection under the skin) dose administrations in healthy men and postmenopausal women with low bone mineral density.

Completed10 enrollment criteria

IGF-1 and Bone Loss in Women With Anorexia Nervosa

Anorexia NervosaOsteopenia1 more

Anorexia nervosa is an eating disorder that can cause thinning of the bones (a decrease in bone density). A significant decrease in bone density is called osteopenia or osteoporosis. Sometimes the loss of bone density can be severe enough to cause breaks and fractures of the bones. It is not known what causes the bones to thin in anorexia nervosa. Women who have this condition often have thin or weak bones that are more likely to break. They also have very low levels of a chemical called IGF-1 in their body. This chemical is very important for increasing bone growth in puberty and for maintaining healthy adult bones. The investigators would like to find out if giving rhIGF-1 followed by risedronate or risedronate alone can lead to an increase in bone formation, bone density, and bone strength in women with anorexia nervosa.

Completed20 enrollment criteria

Romosozumab (AMG 785) in Postmenopausal Women With Low Bone Mineral Density

Low Bone Mineral DensityPostmenopausal Osteoporosis

The primary objective was to determine the effect of treatment with romosozumab versus placebo at month 12 on the percent change from baseline in bone mineral density (BMD) at the lumbar spine in postmenopausal women with low bone density.

Completed36 enrollment criteria

Controlled Study of ONO-5334 in Postmenopausal Women With Osteopenia or Osteoporosis

OsteoporosisOsteopenia

The purpose of this study is to evaluate the efficacy and safety of ONO-5334 in postmenopausal women with osteopenia or osteoporosis.

Completed9 enrollment criteria

High Dosage Vitamin D and Osteoporosis

OsteoporosisOsteopenia

Vitamin D and calcium are essential in the treatment and prevention of osteoporosis. What dosage of vitamin D which is the ideal one, is not yet clear. We want to test the hypothesis that high dosage of vitamin D (i.e. 6500 IU/d) is better than standard dosage (800 IU/d) in a randomized double-blind trial. We will include 400 postmenopausal otherwise healthy women with T-score <= -2.0 in L2-4 or mean total hip. Everybody will receive calcium 1000 mg and vitamin D 800 IU every day. Half of the group will also receive vitamin D 40 000 IU/week, while the other half will have placebo. The study period is one year.

Completed8 enrollment criteria

A Study of Bonviva (Ibandronate) Once Monthly in Post-Menopausal Women With Osteopenia.

Post-Menopausal Osteopenia

This 2 arm study will compare the effect of oral Bonviva (150mg, monthly) and placebo on parameters of bone micro-architecture, assessed by CT scan, bone turnover and bone mineral density. Patients will be randomized to receive either Bonviva 150mg po or placebo monthly, and measurements will be taken at baseline, and at intervals over 2 years. The anticipated time on study treatment is 2+ years, and the target sample size is 100-500 individuals.

Completed4 enrollment criteria

Does Treatment of Hypovitaminosis D Increase Calcium Absorption?

OsteoporosisOsteopenia4 more

The purpose is to perform a one-year study designed to assess whether treatment of hypovitaminosis D increases intestinal absorption of calcium, subsequent retention of calcium within bone, decreases bone turnover, and favorably impacts upon skeletal muscle mass, functional status, measures of physical function and quality of life. I hypothesize that treatment of hypovitaminosis D results in improved intestinal calcium absorption, greater retention of calcium within the bone reservoir and improved physical function, quality of life and muscle mass.

Completed13 enrollment criteria

Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia

Osteopenia

This study will compare the ability of two types of long term (12 months) weight-bearing exercise treatments (1. high-intensity jumping and 2. weight lifting) to increase bone mass of the total body, spine and hip in physically active men with osteopenia.

Completed12 enrollment criteria

Using Soy Estrogens to Prevent Bone Loss and Other Menopausal Symptoms

MenopauseOsteoporosis1 more

The purpose of this study is to determine if soy-derived phytoestrogens (naturally occurring compounds similar to estrogen) can prevent bone loss and other menopausal symptoms in women who have recently gone through menopause. Study hypothesis: Tablets of high-dose, purified soy phytoestrogens spare the normally occurring spinal bone loss and improve biological and other emotional changes of menopause.

Completed13 enrollment criteria
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