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Active clinical trials for "Brain Neoplasms"

Results 181-190 of 1541

A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases

Brain Metastases

This study will be a non-randomized phase II trial for patients with one to six brain metastases, at least one of which is appropriate for surgical resection. Upon registration, patients will be assigned to receive neo-adjuvant stereotactic radiosurgery (NASRS).

Recruiting18 enrollment criteria

Study of Osimertinib + SRS vs Osimertinib Alone for Brain Metastases in EGFR Positive Patients With...

Lung Cancer Non-small Cell Stage IVBrain Metastases

This open-label, multicenter, randomized phase II study will evaluate the usage of osimertinib alone for brain metastases compared to SRS and osimertinib in patients with newly diagnosed, treatment naiive EGFR positive lung cancer.

Recruiting26 enrollment criteria

Preoperative Stereotactic Radiosurgery for Brain Metastases

Brain Metastases

STEP is a French multicentre, prospective, non-randomized, phase II study designed to assess 6-months local control after pre-operative stereotactic radiosurgery (SRS) for patients with brain metastases

Recruiting29 enrollment criteria

Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot...

Brain TumorBrain Metastases1 more

This study will evaluate the rate of radiation necrosis following treatment with immune checkpoint inhibitor (ICI) treatment and radiation therapy in subjects with metastatic brain cancer. Subjects will be treated with the standard of care immunotherapy followed by radiation therapy via stereotactic radiosurgery at a reduced dose.

Recruiting23 enrollment criteria

Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

Brain TumorHead and Neck Cancer

The goal of this trial is to determine whether it is possible to minimize radiation dose to parts of the brain that are important for thinking and learning in children who require radiation to treat their tumor, and if this will help reduce neurocognitive (thinking and learning) impairments in these patients. Patients with newly diagnosed brain or head and neck tumors who are having radiation therapy will have neurocognitive testing and MRI imaging (both research and for regular care) done as part of their participation in the study. Survivors of childhood brain tumors who completed radiation therapy at least two years before joining the study, and have not had a recurrence, will have neurocognitive testing and research MRIs completed. Healthy children will also be enrolled and have research MRIs done. The researchers will use the radiation plan to determine how much radiation was delivered to different parts of the brain. The investigators will use the MRIs to determine how the normal brain is changing after treatment; and how this compares to patients who had standard radiation treatment or who never had a brain tumor. The neurocognitive testing will be compared among different groups to see how different treatment plans affect performance on neurocognitive tests.

Recruiting20 enrollment criteria

Stereotactic Radiosurgery Dose Escalation for Brain Metastases

Brain Metastases

This is a Phase I dose escalation and expansion trial. The purpose of this study is to determine the maximum tolerated dose of radiation received during stereotactic radiosurgery in patients with brain metastases who have never received radiation to the brain before.

Recruiting23 enrollment criteria

Intraoperative Brain Shift Calculation Study

TumorBrain3 more

The purpose of the study is to calculate magnitude, type of intraoperative brain shift and assess possibility of it's prediction.

Recruiting11 enrollment criteria

Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations

TumorBrain2 more

The purpose of the study is to assess accuracy, advantages of functional neuronavigation and calculate safe distance from motor areas to brain tumors and vascular malformations in image-guided surgery.

Recruiting16 enrollment criteria

Fitness to Aid the Brain and Cognitive Skills

Pediatric Brain TumorCognitive Impairment

The study will assess the feasibility of a pilot clinical trial of community-led aerobic exercise training for paediatric brain tumour survivors (PBTS) and the feasibility of a web-based platform to deliver this exercise training. It is hypothesized that 12 weeks of community-led exercise training will be feasible for PBTS and the web-based platform will be feasible to deliver exercise training by community-based instructors.

Recruiting15 enrollment criteria

Preop fSRS for Resectable Brain Metastases

Brain MetastasesBrain Lesion

The purpose of the study is to determine whether treatment with pre-operative hypofractionated stereotactic radiosurgery followed by surgery will improve time to local failure (TTLF) compared to the current standard of care.

Recruiting29 enrollment criteria
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