Topiramate 25 mg Tablets Under Fed Conditions
HealthyThe objective of this study was to compare the rate and extent of absorption of topiramate 25 mg tablets (test) versus Topamax® (reference) administered as 2 x 25 mg tablets under fed conditions.
Bioequivalence Study of Topiramate Tablets 25mg Under Fed Conditions
HealthyThe objective of this study was to compare the single-dose relative bioavailability of Ranbaxy and Ortho-McNeil Pharmaceutical (Topamax®) 25 mg topiramate tablets following a 50 mg dose under fed conditions.
Bioavailability Study of Propranolol Under Fed Conditions
To Determine Bioequivalence Under Fed ConditionsTo compare the single-dose bioavailability of Propranolol 160 Mg ER Capsules with Inderal-La
Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting and Fed Conditions
To Determine Bioequivalence Under Fed ConditionsTo compare the single-dose bioavailability of Par and Bristol-Myers Squibb Buspirone HCl Tablets
Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fed Conditions
HealthyThe objective of this study is to compare the rate and extent of absorption if amlodipine-benzazepril 10 mg-20 mg capsules (test) versus Lotrel® (reference),administered as 1 x 10 mg- 20 mg capsule under fed conditions.
Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa
HIV InfectionsHIV/AIDS10 moreThe purpose of this early Phase 2 comparison trial is to evaluate the impact of community health worker (CHW) home visitors on pregnant women and their children in a rural setting in the rural Eastern Cape of South Africa. The intervention provided by the CHWs targets underweight children, mothers living with HIV (MLH), mothers using alcohol, and depressed mothers with the goal of supporting pregnant women to improve birth outcomes, decrease the number of children born with a low birthweight, and develop child caretaking skills over time. UCLA has identified and matched four areas surrounding primary health care clinics: two intervention areas in which this CHW program has been running for one year, and two control areas without the program. Mothers in the research area are followed for one year after giving birth.
Chronic Malnutrition and Oral Health Status in Children Aged One to Five Years
MalnutritionChildMalnutrition is a public health problem that can exert a negative impact on the general and oral health of children. The aim of the present study was to evaluate the effect of chronic malnutrition on the oral health of children aged one to five years. An observational, analytical, cross-sectional study was conducted at the Nutritional Recovery Center and involved 82 children between 12 and 71 months of age. Nutritional status was evaluated using anthropometric indicators and oral health status was measured using the dmft index. Non-stimulated saliva was collected. Flow rate and buffering capacity was then measured with the aid of a pH meter.
Organization of the Dietetic Service in a Hospital
Nutritional DiseaseMalnutritionIn Denmark the dieticians can be organized centrally and called upon if needed, or locally in larger units, or very locally related to bed-units. The organization form is based on tradition not on measurements of quality. We wanted to compare the very local form with the traditional centralized. Methods: Randomized, unblinded, parallel design. The intervention group (IT) was nutritionally handled by the dietician, and the control group (C) by the nurses as previously with the possibility for dietetic help from the center.
A Natural Experiment Evaluating the Effect of a Minimum Wage Increase on Obesity and Diet-related...
ObesityNutrition PoorTo evaluate the effect of the Minneapolis minimum wage ordinance on change in body mass index among low-wage workers.
Maternal B12 Supplementation to Improve Infant B12 Deficiency and Neurodevelopment
Child Developmental DelayChild Malnutrition2 moreVitamin B12 plays a key role in the development and normal functioning of the brain and nervous system. Unborn and new-born infants derive their vitamin B12 stores almost entirely from maternal B12 stores. As such, infants who are born to vegetarian mothers and exclusively breast fed are at a high-risk of B12 deficiency. This is because the best sources of vitamin B12 are found in animal based or fortified foods (e.g. cheese, milk and eggs). Vitamin B12 deficiency is widely reported among antenatal mothers and children, particularly in Low and Middle Income Countries (LMICs) where these food sources are uncommon. So far, studies have shown that antenatal vitamin B12 deficiency in mothers may be associated with poorer neurodevelopment in their children. Furthermore, vitamin B12 supplementation during pregnancy and early lactation has been shown to increase maternal, breast milk, and infant levels of vitamin B12. Although existing literature documents several studies on maternal vitamin B12 supplementation, there is a lack of research on the causative effect of maternal vitamin B12 supplementation on infant development. This project, funded by the Medical Research Council (MRC), will undertake a multi-centric nutritional trial in Nepal and India, as these are two LMICs where high incidence of vitamin B12 deficiency is reported.