A Study to Assess the Efficacy of Intravenous Bondronat (Ibandronate) in Patients With Malignant...
PainBone Neoplasm1 moreThis 2 arm study will compare the efficacy of intravenous Bondronat with that of zoledronic acid in patients with malignant bone disease experiencing moderate to severe pain. Patients will be randomized to receive either Bondronat (6mg iv on days 1, 2 and 3 and then every 3-4 weeks) or zoledronic acid (4mg iv on day 1 and then every 3-4 weeks). The anticipated time of study treatment is 6-12 months, and the target sample size is 100-500 individuals.
Zoledronic Acid Administration to Metastatic Breast Cancer Patients With Non-symptomatic Bone Lesions...
Breast CancerNeoplasm MetastasisThis is an open-label, randomized, multicenter phase III trial to assess the efficacy of early administration of zoledronate versus observation in delaying bone-related symptoms in metastatic breast cancer patients.
Study of Oxaliplatin, Capecitabine, and Bevacizumab to Treat Older Patients With Colorectal Cancer...
Colorectal CancerNeoplasm MetastasisCurrently there is no one standard of care for older patients with metastatic colorectal cancer. The study will examine the tumor response to capecitabine, oxaliplatin, plus bevacizumab. The study will also gather information on the usefulness and side effects of this treatment combination.
Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer
Brain NeoplasmsNon Small Cell Lung CancerThe aim of the study is to determine if Iressa is effective in the treatment of Brain metastases from NCSLC
Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study...
MetastasesNeoplasm3 moreBrain metastases from solid tumors are diagnosed in more than 300,000 patients annually. Nonsmall cell lung cancer accounts for the majority of CNS mets. Treatment with whole brain radiation and steroids will improve neurologic symptoms in about 50% of patients although survival is short. This study will test the safety and efficacy of temozolomide in combination with radiation therapy in the treatment of patients with brain mets form nonsmall cell lung cancer.
Interleukin-12 Gene Therapy in Treating Patients With Skin Metastases
Metastatic CancerRATIONALE: Inserting the gene for interleukin-12 into a person's skin tumor cells may make the body build an immune response to kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of interleukin-12 gene therapy in treating patients who have skin metastases.
Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases
Brain MetastasesGeneralized Malignancy2 moreThe main purpose of this study is to see whether addition of TPI 287 to FSRT is safe and tolerable. Researchers also want to find out if adding TPI 287 to FSRT can help with better controlling the growth of brain lesions in people with brain metastases from their cancer.
Study Evaluating the Biologic Activity of Guanabenz in Bone Metastasis
Bone CancerMetastasisThis study will explore the biologic activity of guanabenz in reducing bone turn over in solid tumor patients with bone metastasis. If successful, this repurposing of an already, generic drug could benefit patients faster than manufacturing a novel expensive compound.
BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis
Multiple SclerosisSecondary ProgressiveThe primary objective of the study is to investigate whether treatment with BG00012 (dimethyl fumarate) compared with placebo slows the accumulation of disability not related to relapses in participants with secondary progressive multiple sclerosis (SPMS). The secondary objective of the study is to assess the effect of BG00012 compared with placebo on patient-reported outcomes, brain atrophy, and cognitive function.
Cryosurgery and Radiation Therapy in Treating Patients With Painful Bone Metastases
Bone MetastasesPainThis pilot clinical trial studies cryosurgery and radiation therapy in treating patients with painful bone metastases. Cryosurgery kills tumor cells by freezing them. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Giving cryosurgery together with radiation therapy may kill more tumor cells