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Active clinical trials for "Migraine Disorders"

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Phase 3 Study of MAP0004 in Adult Migraineurs

Migraine Disorders

This is a randomized, double blind, placebo controlled, parallel group study of MAP0004 in adult migraineurs. Subjects will self administer study drug in the outpatient setting.

Completed7 enrollment criteria

A Study to Evaluate the Efficacy and Safety of Eptinezumab for the Prevention of Migraine in Participants...

Migraine

Evaluation of eptinezumab in the prevention of migraine in participants with unsuccessful prior preventive treatments.

Completed17 enrollment criteria

Efficacy of Inhaled Cannabis for Acute Migraine Treatment

MigraineCannabis2 more

This crossover study will evaluate 3 different treatments of vaporized cannabis (THC, THC/CBD mix, and CBD) and vaporized placebo cannabis for the acute treatment of migraine.

Completed18 enrollment criteria

How Can we Treat Photophobia in Migraine

Migraine DisordersPhotophobia

Photophobia, the aberrantly increased sensitivity to light, is a common symptom in migraine patients and light discomfort is frequently found as a trigger for migraine attacks. In behavioral studies, planned exposure to light was found to reduce headache in migraineurs with photophobia, potentially by increasing habituation to this migraine trigger. Here, neurophysiological mechanisms of light exposure versus light deprivation therapy in migraine patients are investigated using functional magnetic resonance imaging (fMRI). Migraine patients and healthy controls receive light exposure therapy (Flash) and light deprivation therapy (Dark) for one hour daily on 7 consecutive days, in a crossover design with a wash-out period of three months. Study participants keep a diary including items on interictal and ictal photophobia, headache frequency and severity 7 days before, during, and 7 days after the interventions. One week before and one day after both interventions, fMRI using flickering light in a block design is applied. Functional activation is analyzed at whole-brain level and habituation of the visual cortex (V1) is modeled with the initial amplitude estimate and the corrected habituation slope.

Completed13 enrollment criteria

A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine

MigraineEpisodic Migraine

The purpose of this study is to assess whether galcanezumab is superior to rimegepant in the prevention of migraine in participants with episodic migraine. The study duration will be approximately 6 months.

Completed6 enrollment criteria

The MOTS (Medication Overuse Treatment Strategy) Trial

Migraine

There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.

Completed15 enrollment criteria

Tertiary Care With or Without Manual Therapy for Chronic Migraine

Chronic Migraine

The aim of this study is to determine if adding manual therapy to care as usual reduces the discomfort from chronic migraine compared to care as usual alone

Completed12 enrollment criteria

RCT of Non-Invasive Vagus Nerve Stimulation (nVNS) With gammaCore®, for the Acute Treatment of Migraine...

Migraine

This study is a prospective, multi-centre, randomised, double-blind, sham-controlled investigation designed for comparison of two parallel treatment groups: gammaCore (active nVNS treatment) and a Sham device (control treatment), for the acute treatment of migraine attacks

Completed37 enrollment criteria

Nutritional Intervention in Migraine

Migraine

Migraine is a common medical condition. Several studies suggest that obesity and/or weight gain are risk factors for aggravating migraine course, especially increase the frequency of headache episodes. The aim of the current study was to evaluate whether nutritional intervention would be able to improve clinical parameters (as assessed by MIDAS and HIT) of patients with migraine.

Completed6 enrollment criteria

Relative Bioavailability Study of Nadolol (1 x 80 mg) Tablets Under Fasting Conditions

High Blood PressureMigraine Headaches1 more

The purpose of this study is to demonstrate the relative bioavailability of Nadolol (1 x 80 mg) tablets under fasting conditions.

Completed3 enrollment criteria
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