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Active clinical trials for "Multiple Sclerosis"

Results 111-120 of 2848

Study Evaluating Safety and Tolerability of Escalating Single and Multiple Doses of PIPE-791 and...

Multiple Sclerosis

This study will be conducted in three parts: Part 1 will be a Single Ascending Dose (SAD), Part 2 will be a Multiple Ascending Dose (MAD), and Part 3 will be a selected SAD cohort in a fed state. Safety will be assessed by periodic measurement of vital signs, physical examinations, electrocardiograms, blood laboratory analyses and occurrence of adverse events (AE).

Recruiting12 enrollment criteria

A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous RO7121932...

Multiple Sclerosis

The primary purpose of the study is to evaluate the safety and tolerability of single ascending intravenous (IV) doses of RO7121932 in participants with multiple sclerosis (MS)

Recruiting30 enrollment criteria

Use of Audio Recordings of Self-Hypnosis and Meditation for Fatigue Management in Multiple Sclerosis...

Multiple SclerosisFatigue

The purpose of this study is to assess the effectiveness of two self-guided psychological treatments, Self-Hypnosis (HYP) and Mindfulness Meditation (MM) compared to Treatment as Usual (TAU) for people with multiple sclerosis (MS) and clinically significant fatigue.

Recruiting8 enrollment criteria

Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis

Relapsing Remitting Multiple SclerosisSecondary Progressive Multiple Sclerosis1 more

The DanNORMS study is phase 3 non-inferiority clinical trial examining whether treatment of active multiple sclerosis with rituximab is non-inferior to ocrelizumab regarding efficacy and safety.

Recruiting48 enrollment criteria

RC18 in Patients With Relapsing Remitting Multiple Sclerosis:a Phase II Trial

Multiple SclerosisRelapsing-Remitting

To observe the safety and effectivity of a Recombinant Human B Lymphocyte Stimulator Receptor : Immunoglobulin G( IgG ) Fc Fusion Protein for injection (RC18) in patients with relapsing remitting multiple sclerosis, analyze the dose-response relationship and provide a dose basis for follow-up clinical trials.

Recruiting25 enrollment criteria

Pilot Study of the Safety and Tolerability of L-DLPFC iTBS rTMS for MDD in MS

Multiple SclerosisMajor Depressive Disorder

The main purpose of this study is to investigate the safety and tolerability of intermittent Theta Burst (iTBS) repetitive transcranial magnetic stimulation (rTMS), its effectiveness in alleviating depressive symptoms as well as its effects on cognition. Although iTBS rTMS is approved for use, there have been no safety and tolerability evaluations of this form of rTMS in Multiple Sclerosis (MS).

Recruiting24 enrollment criteria

Safety and Efficacy Study of Fingolimod in Taiwanese Adults (≥ 20years) With Relapsing Remitting...

Multiple Sclerosis

The purpose of the study is to describe the safety profile of fingolimod in the Taiwanese multiple sclerosis population. This study aims to collect the safety data in patients newly initiated on fingolimod for one year.

Recruiting11 enrollment criteria

Aerobic Training Effects on Motor and Cognitive Performances in MS: an Exploratory Study With Structural...

Multiple Sclerosis

Aerobic training (AT) induces cardiovascular, metabolic and muscular changes and has been proposed as a promising rehabilitative approach in elderly adults and in neurological patients to improve both motor and cognitive performances. The Investigators wish to explore the role of AT in multiple sclerosis (MS) patients on physical and neuropsychological functions and its underlying anatomical and functional substrates, using advanced magnetic resonance imaging (MRI) methods. In this project, the Investigators wish to apply aerobic training in right-handed MS patients and healthy controls to assess: the effects of aerobic training compared to conventional motor training on motor and cardio-vascular parameters; the effect of aerobic training compared to conventional motor training on cognitive performance, depression and fatigue; the modifications of functional activations during a cognitive task and of functional connectivity in motor and cognitive networks during resting state following aerobic training and conventional motor training (functional plasticity); the regional variations of gray matter (GM) volumes and white matter (WM) architecture after aerobic training and conventional motor training (structural plasticity); the correlations between the changes detected with structural and functional MRI and clinical, motor and neuropsychological scales.

Recruiting19 enrollment criteria

Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis...

Relapsing Multiple SclerosisRelapsing Remitting Multiple Sclerosis1 more

This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for treatment-resistant relapsing multiple sclerosis (MS). Participants will be randomized at a 1 to 1 (1:1) ratio. All participants will be followed for 72 months after randomization (Day 0, Visit 0).

Recruiting64 enrollment criteria

Fecal Microbiota Transplantation After Autologous HSCT in Patients With Multiple Sclerosis

Multiple Sclerosis

The hypothesis of the study is that according to modern data, the pathogenesis of multiple sclerosis is inextricably linked to the patient's microbiota. Therefore, transplantation of a normal fecal microbiota (FMT) can improve the outcome of autologous hematopoietic stem cell transplantation (autoHSCT) by increasing the disease-free period and disease progression suspension for at least 5 years after transplantation, which meets the NEDA (No Evidence of Disease Activity) criteria, satisfying the current trends of clinical neurology.

Recruiting18 enrollment criteria
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