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Active clinical trials for "Multiple System Atrophy"

Results 1-10 of 156

Biomarker Study of ATH434 in Participants With MSA

Multiple System Atrophy

This study will assess the safety and efficacy of ATH434 in participants with a clinical diagnosis of Multiple System Atrophy

Recruiting10 enrollment criteria

Automated Abdominal Binder for Orthostatic Hypotension

Orthostatic HypotensionAutonomic Failure2 more

The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The purpose of this study is to determine safety and effectiveness of the automated abdominal binder in improving orthostatic tolerance in these patients.

Recruiting12 enrollment criteria

Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants...

Symptomatic Neurogenic Orthostatic HypotensionMSA - Multiple System Atrophy

This is a Phase 3, multi-center, randomized withdrawal study to evaluate the efficacy and durability of ampreloxetine in participants with MSA and symptomatic nOH after 20 weeks of treatment. This study includes 4 periods: Screening, open label, randomized withdrawal, and long-term treatment extension (LTE).

Recruiting40 enrollment criteria

Study of ATH434 in Participants With Multiple System Atrophy

Multiple System Atrophy

This study will assess the safety and efficacy of ATH434 in participants with Multiple System Atrophy

Recruiting11 enrollment criteria

Spinal Cord Stimulation for Multiple System Atrophy

Multiple System Atrophy

Spinal Cord Stimulation (SCS) is a newly emerged neuromodulation technique in recent years. It is now a mature technique in the treatment of chronic pain and is generally accepted by patients because of its non-destructive and reversible nature, few complications, no side effects, and avoidance of unnecessary surgical procedures. Combining the results of previous studies and the group's previous research, this study first proposes an innovative treatment protocol for multiple system atrophy with SCS in C2-4 segment. We intend to conduct a prospective single-center open clinical trial to evaluate the improvement of dysarthria, dysphagia, urinary retention and orthostatic hypotension in multiple system atrophy (MSA) patients before and after SCS treatment, and shed new light on the treatment for MSA.

Recruiting12 enrollment criteria

DBS and SCS Therapy Improve Motor Function in Multiple System Atrophy With Predominant Parkinsonism...

Multiple System AtrophyParkinson Variant (Disorder)

Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder and symptomatic therapeutic strategies are still limited.The parkinsonian type of MSA (MSA-P) has parkinsonian symptoms as its prominent manifestation, although Deep brain stimulation (DBS) at the subthalamic nucleus or globus pallidus interna has been an established treatment for Parkinson's disease patients, it is mostly ineffective in MSA-P patients, the improvement in motor function as short-lasting and rapidly followed by the early appearance of freezing of gait (FOG) and postural instability that counteracted DBS benefits and often leads to significant disability and loss of quality of life. Recently, some pilot studies demonstrated the safety and significant therapeutic outcome of SCS for FOG.The purpose of this clinical study is to understand the effectiveness of DBS combined with SCS for symptomatic treatment of MSA-P.

Recruiting8 enrollment criteria

GDNF Gene Therapy for Multiple System Atrophy

Multiple System Atrophy

The objective of this randomized, double-blinded, placebo-controlled Phase 1 investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a possible or probable diagnosis of Multiple System Atrophy.

Recruiting12 enrollment criteria

MotIoN aDaptive Deep Brain Stimulation for MSA

MSA - Multiple System Atrophy

Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), the effects on autonomic parameters such as blood pressure and bladder symptoms has been shown to be improved by the investigators (unpublished data). In this current study, the investigators plan to use a novel technique of adaptive DBS in order to provide stimulation dependent on patient physiological or positional factors. This is with the aim of making stimulation more responsive and patient-specific.

Recruiting15 enrollment criteria

Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early-...

Multiple System AtrophyMSA - Multiple System Atrophy

Purpose of this phase 1/2a study is to assess the safety and efficacy of intrathecal administration of allogeneic human oral mucosa stem cells (hOMSCs) in patients suffering from early to moderate stage Multiple System Atrophy (MSA) .

Recruiting10 enrollment criteria

Trial to Evaluate the Efficacy and Safety of KM-819 Treatment to Slow the Progression of Multiple...

Multiple System Atrophy

This trial will the efficacy of KM-819 compared to placebo in subjects with MSA for slowing the progression of MSA.

Recruiting24 enrollment criteria
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