Biomarker Study of ATH434 in Participants With MSA
Multiple System AtrophyThis study will assess the safety and efficacy of ATH434 in participants with a clinical diagnosis of Multiple System Atrophy
Automated Abdominal Binder for Orthostatic Hypotension
Orthostatic HypotensionAutonomic Failure2 moreThe automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The purpose of this study is to determine safety and effectiveness of the automated abdominal binder in improving orthostatic tolerance in these patients.
Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants...
Symptomatic Neurogenic Orthostatic HypotensionMSA - Multiple System AtrophyThis is a Phase 3, multi-center, randomized withdrawal study to evaluate the efficacy and durability of ampreloxetine in participants with MSA and symptomatic nOH after 20 weeks of treatment. This study includes 4 periods: Screening, open label, randomized withdrawal, and long-term treatment extension (LTE).
Study of ATH434 in Participants With Multiple System Atrophy
Multiple System AtrophyThis study will assess the safety and efficacy of ATH434 in participants with Multiple System Atrophy
Spinal Cord Stimulation for Multiple System Atrophy
Multiple System AtrophySpinal Cord Stimulation (SCS) is a newly emerged neuromodulation technique in recent years. It is now a mature technique in the treatment of chronic pain and is generally accepted by patients because of its non-destructive and reversible nature, few complications, no side effects, and avoidance of unnecessary surgical procedures. Combining the results of previous studies and the group's previous research, this study first proposes an innovative treatment protocol for multiple system atrophy with SCS in C2-4 segment. We intend to conduct a prospective single-center open clinical trial to evaluate the improvement of dysarthria, dysphagia, urinary retention and orthostatic hypotension in multiple system atrophy (MSA) patients before and after SCS treatment, and shed new light on the treatment for MSA.
DBS and SCS Therapy Improve Motor Function in Multiple System Atrophy With Predominant Parkinsonism...
Multiple System AtrophyParkinson Variant (Disorder)Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder and symptomatic therapeutic strategies are still limited.The parkinsonian type of MSA (MSA-P) has parkinsonian symptoms as its prominent manifestation, although Deep brain stimulation (DBS) at the subthalamic nucleus or globus pallidus interna has been an established treatment for Parkinson's disease patients, it is mostly ineffective in MSA-P patients, the improvement in motor function as short-lasting and rapidly followed by the early appearance of freezing of gait (FOG) and postural instability that counteracted DBS benefits and often leads to significant disability and loss of quality of life. Recently, some pilot studies demonstrated the safety and significant therapeutic outcome of SCS for FOG.The purpose of this clinical study is to understand the effectiveness of DBS combined with SCS for symptomatic treatment of MSA-P.
GDNF Gene Therapy for Multiple System Atrophy
Multiple System AtrophyThe objective of this randomized, double-blinded, placebo-controlled Phase 1 investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a possible or probable diagnosis of Multiple System Atrophy.
MotIoN aDaptive Deep Brain Stimulation for MSA
MSA - Multiple System AtrophyPatients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), the effects on autonomic parameters such as blood pressure and bladder symptoms has been shown to be improved by the investigators (unpublished data). In this current study, the investigators plan to use a novel technique of adaptive DBS in order to provide stimulation dependent on patient physiological or positional factors. This is with the aim of making stimulation more responsive and patient-specific.
Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early-...
Multiple System AtrophyMSA - Multiple System AtrophyPurpose of this phase 1/2a study is to assess the safety and efficacy of intrathecal administration of allogeneic human oral mucosa stem cells (hOMSCs) in patients suffering from early to moderate stage Multiple System Atrophy (MSA) .
Trial to Evaluate the Efficacy and Safety of KM-819 Treatment to Slow the Progression of Multiple...
Multiple System AtrophyThis trial will the efficacy of KM-819 compared to placebo in subjects with MSA for slowing the progression of MSA.