
Alcohol, Inflammation and Atherosclerosis
ArteriosclerosisMyocardial InfarctionEffect of moderate alcohol consumption in form of red wine, beer and ethanol solution and corresponding de-alcoholised beverages on immune measures. In healthy middle aged men and women In a randomized controlled cross-over trial Two intervention periods over 3 weeks

AngelMed for Early Recognition and Treatment of STEMI
Acute Myocardial Infarction (AMI)Coronary Occlusion1 moreA prospective, randomized multicenter study of subjects with a high-risk of having a myocardial infarction (MI) due to acute coronary syndrome or bypass surgery. There is no differential intervention administered to the two arms of the ALERTS Study. The study evaluates whether or not a patient alarm from the Guardian System will provide benefit (e.g. shorten pre-hospital delay) compared to symptoms-only ER presentation in the event of a heart attack. An amendment to the data analysis protocol was collaboratively created by AngelMed and FDA, and was adopted by AngelMed on 4/22/2017.

LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin
Coronary Artery DiseaseAcute Myocardial InfarctionTo prospectively evaluate the utility of enoxaparin vs. oral warfarin in reduction of echocardiographic indices of LV mural thrombus. The primary outcome is the presence of LV mural thrombus at 3.5 months. The secondary outcome is cost analysis comparing the two arms.

Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute...
Unstable AnginaMyocardial InfarctionThis is a randomized, double blind, placebo-controlled study, clinical trail designed to evaluate the efficacy safety and superiority of intravenous boluses of isosorbide dinitrate for the relief of acute anginal pain episodes in acute coronary syndrome patients in comparison with the usual manner of S/L isosorbide dinitrate .

Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients
Myocardial InfarctionStatins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduce cardiovascular events including heart failure in acute myocardial infarction patients. The purpose of this study is to determine whether early (within 96 hours after onset) use of any available statins are effective to prevent cardiovascular events including heart failure after acute myocardial infarction in Japanese patients.

Vitamin Therapy for Prevention of Stroke
StrokeCerebral Infarction1 moreA stroke occurs when part of the brain is damaged from lack of normal blood supply. This may result in difficulty with feeling, speech, muscle strength or coordination, movement, thinking, or other brain functions. Having a stroke increases the risk of another stroke occurring in the future. Higher blood levels of a natural chemical known as homocysteine may contribute to hardening of the arteries in the brain or heart and increase the risk of stroke or heart attack. Folic acid, vitamin B6 (pyridoxine), and vitamin B12 (cyanocobalamin) may lower blood levels of homocysteine and reduce the risk of having another stroke or a heart attack.

Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
ArrhythmiaCardiovascular Diseases4 moreTo compare the efficacy of amiodarone to conventional anti-arrhythmic therapy in individuals who had survived one episode of out-of-hospital cardiac arrest.

Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary...
Cardiovascular DiseasesCerebrovascular Disorders5 moreThe purpose of this study is to evaluate the effects of low-dose aspirin and vitamin E in primary prevention of cardiovascular disease and cancer in apparently healthy women.

Early Treatment With Evolocumab in Patients With ST-elevation Myocardial Infarction
ST-elevation Myocardial InfarctionThis is a prospective, multi-centre, open label, randomised study of Phase II that enrolls patients hospitalized with a diagnosis of ST-elevation myocardial infarction (STEMI), comparing Evolocumab versus Standard of Care.

The Box: Using Smart Technology to Improve One-year Outcome of Myocardial Infarction Patients
Myocardial InfarctionStudy to investigate whether a smart technology intervention can improve clinical and cost-effectiveness of one-year follow-up in patients who suffered from acute myocardial infarction.