Preliminary Administration of EPO and Markers of Cardiac Ischemia Induced by CPB
Myocardial IschemiaThe main objective is to observe the effects of erythropoietin administration on different blood markers of ischaemic cardiac lesions induced by cardiopulmonary bypass.
Evaluation of M118 in Percutaneous Coronary Intervention (EMINENCE)
Coronary Artery Disease (CAD)The primary objective is to evaluate the safety and feasibility of using M118 as an anticoagulant in the target population of subjects with stable coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). The secondary objectives are to evaluate the effect of M118 on procedural indices including procedure success, abrupt closure, post-procedure TIMI flow, and catheter thrombus. Substudy Primary Objective The primary objective of the substudy is to characterize the pharmacokinetic and pharmacodynamic profile of M118 among subjects with stable coronary artery disease undergoing elective PCI.
PET and Recovery Following Revascularization (PARR 2)
Coronary Artery DiseaseVentricular Dysfunction1 moreRationale: Patients with severe ventricular dysfunction and coronary disease have high morbidity and mortality. They may benefit from revascularization, but have significant peri-operative morbidity and mortality. Positron emission tomography (PET) imaging with F-18-fluorodeoxyglucose (FDG) can detect viable myocardium that may recover from revascularization in such patients. It is unclear whether use of FDG PET in this population is improves outcome or is cost-effective. Objectives: The principal aim is to determine whether FDG PET-guided therapy is effective versus standard care. Secondary objectives are to determine whether FDG PET-guided therapy improves LV function, quality of life and is good value for money versus standard care.
The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular...
Coronary Heart DiseaseTo study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.
Iodixanol vs. Iomeprol to Prevent Contrast-Induced Nephropathy After Coronary Intervention (CONTRAST)...
Renal InsufficiencyChronic4 moreThe purpose of this study is to demonstrate that Iodixanol 320 is associated with a lower incidence of contrast-induced nephropathy (CIN) when compared with hyperosmolar contrast medium Iomeprol 350 in patients with impaired renal function undergoing percutaneous coronary interventions (PCI).
Add-on Effects of Valsartan on Morbi- Mortality (KYOTO HEART Study)
HypertensionIschemic Heart Disease2 moreThe KYOTO HEART Study is to assess the add-on effect of valsartan, an Angiotensin-Receptor Blocker, on top of the conventional treatment in high risk patients in Japan with hypertension in terms of the morbidity and mortality.
Enhancing Support for Women at Risk for Heart Disease
Cardiovascular DiseasesHeart Diseases4 moreTo test a practical, theory-based intervention to achieve long-term behavior change for postmenopausal women with Type 2 diabetes at high risk for developing coronary heart disease (CHD).
Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial
Heart DiseaseStroke2 moreThe purpose of this study is to determine which of two treatments, Warfarin or aspirin, is better for preventing death and stroke in patients with poor heart function. We are now transitioning into the sub-analysis part of the WARCEF patient data. The study has recently completed data analysis for its Primary Aim. All randomized patients have completed their follow up. All study related procedure as per the protocol has been completed. We are now in the extension phase of the study to obtain more patient data to address further aims of the study. No new procedures are performed and data already in place at the sites will be collected (EKG and echocardiograms). The aims for this study extension are: To assess progression of cardiac dysfunction over time among heart failure patients To correlate prognosis with cardiac dysfunction
Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
Cardiovascular DiseasesCoronary Arteriosclerosis4 moreTo determine if supplements of vitamin C, vitamin E, beta-carotene, and B-vitamins (a combination of folic acid, vitamins B6 and B12) reduce risk of major cardiovascular events in high risk women with a prior history of atherosclerotic cardiovascular disease. The trial is a companion to the Women's Health Study (WHS), a primary prevention trial of vitamin E and aspirin in a low risk population of women.
Estrogen Replacement and Atherosclerosis (ERA) in Older Women
Cardiovascular DiseasesCoronary Arteriosclerosis4 moreTo determine if estrogen replacement therapy, with or without low dose progesterone, slows progression or induces regression of coronary atherosclerosis in postmenopausal women.