A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around...
Central Retinal Vein OcclusionChoroidal Neovascularization2 moreThis is a research study to evaluate the effects of repeated intravitreal injections on bacteria around the eye.
Corneal Thinning During Topical Bevacizumab Therapy
Corneal NeovascularizationThe purpose of this study is to determine whether topical bevacizumab is safe or not when used in corneal neovascularization for long term period.
High Myopia: Extended and Longterm Observation of Pathologic Myopia Patients With the Risk for Developing...
Pathologic MyopiaThis research project intends to observe patients with high myopia who show pathological retinal changes, in order to evaluate more data on the risk factors for developing mCNV within this research project population in Germany.
Serum Biomarker of Plaque Vulnerability and Contrast Ultrasound of Carotid Artery
Intraplaque Neovascularization Evaluated by Carotid Enhanced Ultrasound Well Reflect the Plaque VulnerabilityNo serum biomarker has qualified for clinical use until now. However several biomarkers, especially markers of inflammatory or proteolytic activity seem to promising in the identification of vulnerable plaques. Moreover, recent study confirmed that contrast-enhanced ultrasound imaging(CEUS) can visualize intraplaque neovascularization and represent the plaque vulnerability. In this study we try to identify indicators through analysis of the relationship between plaque neovascularization seen by CEUS and well known biomarkers such as serum matrix metalloproteinase(MMP)-2, MMP-9, cathepsin family(L,S,V), cystatin C, lipoprotein phospholipase A2, and hs-crp
Examining Macrophage Influx and Vascularization in Chronic Pancreatitis
PancreatitisDiabetesOur aim in this study is to find out if we can locate the similar reduction in the recruitment of macrophages, remodeling of vasculature and do they correlate in the number and area of the islets in pancreas as in the mouse model.
Screening for Studies on Retinovascular Diseases
Diabetic RetinopathyMacular Degeneration2 moreThis screening protocol is designed to help recruit patients for National Eye Institute (NEI) studies of the retina, such as diabetic retinopathy and macular degeneration. Patients must meet the specific criteria of a research study, and this protocol serves as a first step for admitting patients to a retinal disease study. Candidates will undergo a medical history and comprehensive eye examination. The eye examination includes dilation of the pupils to fully examine the retina. In some studies, photographs of the eye are required. This is done using fluorescein angiography. In this procedure, a dye called sodium fluorescein is injected into the blood stream through a vein. After the dye reaches the blood vessels of the eye, photographs are taken of the retina. Other diagnostic procedures may include physical examination, questionnaires, routine laboratory tests and other standard or specialized tests, as needed. When the screening is completed, patients will be informed of their options to participate in a study. Patients who are ineligible for a current study will be informed of alternative treatments or options. No treatment is offered under this protocol.
Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal...
Choroidal NeovascularizationPunctate Inner ChoroidopathyTo evaluate the long-term outcome of active choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) after anti-vascular endothelial factor treatment.
Daily Testing at Home by NV-AMD Subjects With Notal Home OCT.
Retinal NeovascularizationThe purpose of this study is to evaluate the ability of subjects with NV-AMD to perform sequential daily self-imaging of their eyes with the self-operated Notal Home OCT device in their homes for 90 days without on-site supervision. The study will include up to 15 subjects.
Impact of Nicotine on Retinal Vascularization
TabagismThe main hypothesis is the nicotine is associated with a modification of retinal micro-vascularization. Patients will be recruited during their ophthalmologic consultation at the Rothschild Foundation, an OCT-A will be realized and data relating to medical history, oral contraceptive intake and nicotine consumption via cigarette or e-cigarette data will be collected. The objective is to seek an association between retinal vascular density and inhaled nicotine intake.
Characterization of Early Markers of Choroidal Neovascularization
Age-related Macular DegenerationTo this study and identify the sequence of alterations occurring in the chorioretinal interface during progression of AMD from "dry" AMD to sight-threatening chorioretinal neovascularization (CNV).