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Active clinical trials for "Lupus Nephritis"

Results 161-170 of 206

The Effect of Calcitriol on Progress and Activity of Lupus Nephritis

Systemic Lupus Erythematosus

The purpose of this study is to determine whether calcitriol is effective in the treatment of lupus nephritis.

Unknown status20 enrollment criteria

Efficacy and Safety of Tamibarotene(AM80) for Lupus Nephritis

Lupus Nephritis

An open-label study to evaluate the efficacy and safety of orally administered Tamibarotene to patients of Lupus Nephritis

Unknown status15 enrollment criteria

Effect of Mesenchymal Stem Cell Transplantation for Lupus Nephritis

Lupus Nephritis

Mesenchymal Stem Cell (MSC) has been shown to have immunosuppressive and repairing properties. Manifestations of systemic lupus eryhematosus(SLE) may in most patients be ameliorated with medications that suppress the immune system. Nevertheless, there remains a subset of SLE patients for whom current strategies are insufficient to control disease. The investigators will infuse expanded autologous MSC into patients with lupus Nephritis. The purpose of this trial is to evaluate whether this new therapeutical approach will result in improvement in the lupus disease.

Unknown status11 enrollment criteria

Iguratimod as Treatment for Refractory Lupus Nephritis

Lupus Nephritis

This study is to evaluate the efficacy and safety of a novel chemical synthetic agent iguratimod as treatment of refractory lupus nephritis. All subjects should have at least one failed immunosuppressive treatment and suffer active nephritis at the screening stage. The study period is 52 week. All the subject will receive therapy of iguratimod combined with steroids.

Unknown status16 enrollment criteria

The Iguratimod Effect on Lupus Nephritis (IGeLU)

Lupus Nephritis

This study is a 52-week, randomized, open, active-controlled trial of patients with active diffused lupus nephritis, to assess the efficacy and safety of a novel chemical synthetic agent iguratimod. The subjects will randomly receive iguratimod or cyclophosphamide followed with azathioprine, both combined with steroids.

Unknown status19 enrollment criteria

Leflunomide Versus Azathioprine for Maintenance Therapy of Lupus Nephritis

NephritisLupus

Leflunomide versus Azathioprine for Maintenance Therapy of Lupus Nephritis

Unknown status13 enrollment criteria

A Phase II Study to Evaluate the Efficacy and Safety of SHR-1314 in Lupus Nephritis

Lupus Nephritis

To demonstrate the efficacy of SHR-1314 at Week 12 in subjects with proliferation lupus nephritis in terms of improvement of 24h UPCR, compared to placebo. The study will also assess the safety and tolerability of SHR-1314 in the patient population over the study period.

Unknown status23 enrollment criteria

Human Umbilical Cord Mesenchymal Stem Cells Treatment for Lupus Nephritis (LN)

Lupus Nephritis

Lupus nephritis (LN) is one of the most serious complications and the main cause of death in patients with systemic lupus erythematosus (SLE).The investigators have investigated the usefulness, and confirmed the efficacy and safety of mesenchymal stem cells (MSC) treatment of LN in animal models, in vitro experiments and phase I clinical trial. In this study, a randomized, placebo-controlled, parallel group, non-inferiority, prospective, multicenter clinical trial is performed to investigate the efficacy and safety of MSC transplantation in the treatment of LN compared to mycophenolate mofetil (MMF).

Unknown status19 enrollment criteria

Efficacy and Safety of Tripterygium Wilfordii in Patients With Lupus Nephritis

NephritisLupus

Evaluation the clinical efficacy and safety profile of glucocorticosteroid combined with oral T2 (chloroform/methanol extract of Tripterygium wilfordii Hook F) in the treatment of patients with lupus nephritis. Open-labeled, randomized, prospective multi-center clinical trial. Observation period of 24 weeks.

Unknown status12 enrollment criteria

Umbilical Cord Mesenchymal Stem Cell Transplantation for Lupus Nephritis

Lupus Nephritis

To investigate the safety and efficacy of umbilical cord mesenchymal stem cell transplantation in patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN).

Unknown status14 enrollment criteria
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