Bioavailability of Vagantin® Coated Tablets Relative to an Oral Methantheline Bromide Solution
Neurogenic BladderThe primary objective of the study is: •To describe extent and rate of absorption of methantheline after single oral dose administration of Vagantin® coated tablets (Test) in comparison to a methantheline bromide solution (Reference) The secondary objectives of the study are: To determine elimination the half-life of methantheline bromide To describe the effects of Test and Reference on salivation, accommodation, pupil response, blood pressure and heart rate to assess frequency and intensity of adverse drug reactions
Connected Catheter Clinical Feasibility Study( CFS)
Urinary BladderNeurogenicThe objective of this study is to evaluate the safety and essential performance of the Connected Catheter System in males with neurogenic lower urinary tract dysfunction (NLUTD), both in an acute clinical setting, and during and extended period (up to 29 days) of home use.
Bilateral vs. Unilateral Stimulation in Neurological Bladder Disroders
Neurogenic Urinary BladderSpasticThis study evaluates the effectiveness of bilateral stimulation of the tibial nerve compared to unilateral stimulation in neurological bladder disorders.
Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction
Neurogenic BladderThe purpose of this study is to determine whether Tamsolusin or Prazosin are effective in the treatment of female voiding dysfunction(BOO)
Mirabegron and Oxybutynin Safety and Efficacy Trial in Spinal Cord Injury
Spinal Cord InjuriesUrinary Bladder1 moreThe purpose of this research study is to determine the effectiveness and safety of mirabegron compared to oxybutynin chloride immediate release (oxybutynin IR) for a condition called neurogenic detrusor overactivity in individuals with chronic spinal cord injury (SCI).
Antiseptic-coated Intermittent Urinary Catheter
Neurogenic BladderCatheter-Related InfectionsStudy design is a prospective, randomised, double-blind, and interventional. Primary aim of the study is to investigate efficacy of antiseptic-coated intermittent hydrophilic urinary catheters in prevention and reduction of catheter-associated urinary tract infections in children with neurogenic bladder. Secondary aim is to assess feasibility of antiseptic-coated intermittent hydrophilic urinary catheters in neurogenic bladder management. Octenidine chloride will be used as antiseptic.
Treatment of Neurogenic Incontinence by Surgery to Cut the Filum Terminale
Neurogenic IncontinenceDysfunctional VoidingThe target population of this study is children with primary or secondary daytime urinary incontinence, who have failed to improve adequately despite compliance with at least 6 months of standard medical therapy. The study hypothesis is that patients who under go cutting the filum terminale - the string-like lower end of the spinal cord - will have improved bladder function at 6-month follow up. Bladder function and its effects on quality of life will be measured before surgery and at 6-month follow up.
Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Neurogenic BladderMyelomeningocelePatients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure. Aim: To evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative diagnostic method to identify detrusor overactivity in patients with neurogenic bladder
Incidence of Urinary Tract Infection After Urodynamic Investigation
Neurogenic BladderThe purpose of this study is to evaluate the incidence of urinary tract infection after urodynamic investigation and to identify the involved germs.
Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for...
Neurogenic BladderSpina BifidaThe primary aim of this study was to determine if using the SpeediCath hydrophilic catheter would reduce the incidence of symptomatic urinary tract infections (UTI)in children with spina bifida who perform clean intermittent catheterization for bladder management. The hypothesis was that the incidence of symptomatic urinary tract infections would be significantly reduced (by 25%) in users of the SpeediCath hydrophilic catheter when compared to users of a reused polyvinyl chloride (PVC) catheter. Subjects were randomly assigned to either starting the study with PVC catheter for 6 months followed by the hydrophilic catheter for 6 months or visa versa. Each subject kept a weekly diary recording urinary tract infections symptoms, hematuria determined by urine dipstick, physician visits, days of missed school and other activities. At the end of each 6 months subjects completed a questionnaire recording their comfort and satisfaction in using the PVC or hydrophilic coated catheter. 70 subjects were randomized and 46 had complete data. There were no differences in febrile UTI, antibiotic use, healthcare visits or school days missed. The incidence of self reported UTI was lower in the PVC group than the hydrophilic group. 40% of subjects indicated that the hydrophilic coated catheter was slippery and difficult to handle compared to 10% for the PVC catheter. However overall satisfaction was no different between products. The study results are consistent with the current Cochrane Review that there is a lack of evidence to state that the incidence of UTI is affected by multiuse or hydrophilic catheter use.