Active clinical trials for "Nevus"

Background: Melanocytic nevi, or "moles," are non-cancerous growths of a type of skin cell called a melanocyte. Large congenital melanocytic nevi (LCMN) are a special type of mole that begins to grow before birth and is larger than moles that develop after birth. Determining how melanocytes in moles and LCMNs differ from normal melanocytes may increase the ability to predict whether a mole will give rise to a melanoma (a type of skin cancer) Objectives: To understand how melanomas develop, by studying moles, LCMNs, and pigmented skin lesions that are suspicious for melanoma To develop better criteria for diagnosing melanoma, particularly by using a device called a digital dermatoscope (a special camera, connected to a computer, that takes pictures of moles when they are magnified and illuminated) Eligibility: Children 5 years old or older with an LCMN Adults 18 years old or older with 100 or more moles larger than 2 mm in diameter and at least one 4 mm or more Adults 18 years old or older with a pigmented lesion suspicious for melanoma Design: Patients' personal and family health history is obtained. Patients are examined by investigative team doctors, and several lesions are examined with a dermatoscope. Additional photographs of part or all of the skin surface may be taken. Some lesions may be biopsied. Additional tests or examinations may be recommended. Patients are followed periodically for skin or physical examinations, photography, laboratory and imaging evaluations, and possible skin biopsies. Children may undergo brain magnetic resonance imaging (MRI)

The Sponsor has developed the Skin Fluorescent Imaging (SFI) system, an in vivo imaging modality, for the purpose of providing physicians with insight into the biological changes occurring during tissue remodeling in a nevus.

A retrospective study on efficacy and complication of laser treatment (Q-switched Nd:YAG and picosecond laser) of nevus of Ota in Thai patients

The purpose of this study is to obtain skin spectroscopic data from two imaging systems. Comparison groups: Skin Spect dermoscope Spatially modulated quantitative spectrometer

Our working hypothesis is that reflectance confocal microscopy (RCM) can identify distinct subsets of melanocytic nevi that retain their distinctive pattern over time.

The BAP1 trial will examine the blood of patients diagnosed with choroidal nevi or uveal melanoma for a germline BAP1 mutation and other genetic markers associated with developing malignancy as well as additional sequencing of the uveal melanoma genome.

The investigators' goal is to identify the mutation in the gene that is responsible for the development of segmental dysplastic nevi. To identify the gene the investigators may use a candidate gene approach (i.e. sequence specific genes that are thought to be involved: NRAS, BRAF, etc) or a genome-wide approach trying to implicate regions in the genome (Loss-of-heterozygosity or copy number changes on comparative genomic hybridization).