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Active clinical trials for "Opioid-Induced Constipation"

Results 31-40 of 91

Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in...

CancerBowel Dysfunction

Study SB-767905/008 was a multicenter study to evaluate the effectiveness and safety of multiple dosage regimens of an investigational drug for the treatment of constipation due to prescription pain medication in participants with cancer pain. Study ABD101684 will serve as an extension to Study SB-767905/008 and offer continued access to blinded investigational product to participants who have completed the original study. The purpose of Study ABD101684 is to evaluate the safety and efficacy of alvimopan compared to placebo in subjects who completed Study SB-767905/008 and elected to participate in this extension study.

Completed10 enrollment criteria

Colonic Motor Patterns in Healthy Volunteers

Opioid-Induced Constipation

Characterization of motor patterns with opioid agonists (codeine) ingestion, and their reversal by a peripherally acting mu-opioid receptor antagonist (Naloxegol).

Completed27 enrollment criteria

Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation...

Opioid-Induced Constipation (OIC)

The purpose of this study is to evaluate the effect and safety of NKTR-118 treatment of opioid-induced constipation in patients with non-cancer-related pain, including those patients that have inadequate response to laxative therapy (LIR).

Completed10 enrollment criteria

Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation...

Opioid-Induced Constipation (OIC)

The purpose of this study is to evaluate the effect and safety of NKTR-118 treatment of opioid-induced constipation in patients with non-cancer-related pain, including those patients that have inadequate response to laxative therapy (LIR).

Completed9 enrollment criteria

Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced Constipation

Opioid-induced Constipation

The purpose of this study is to evaluate the efficacy and safety of naldemedine in the treatment of opioid-induced constipation (OIC) in adults with non-malignant chronic pain who are not using laxatives.

Completed13 enrollment criteria

Long Term Safety of Naldemedine

Opioid-induced Constipation

The purpose of this study is to evaluate the long-term safety of naldemedine for the treatment of constipation due to opioid therapy.

Completed11 enrollment criteria

Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced...

Constipation

Morphine and related opioid analgesics are known to slow gastrointestinal (GI) motility and reduce intestinal secretion through their binding to μ opioid receptors (MORs) within the GI tract. The most common symptoms associated with the effects of opioids are constipation and nausea and/or vomiting. Moreover, constipation is a common and distressing side effect of long-term opioid therapy. The primary objective of this study was to compare ADL5945 once daily, a MOR antagonist, with placebo in the treatment of opioid-induced constipation (OIC) in adults taking long-term opioid therapy for chronic noncancer pain.

Completed24 enrollment criteria

Study to Evaluate the Safety and Efficacy of Naldemedine (S-297995) for the Treatment of Opioid-Induced...

Opioid Induced Bowel Dysfunction

The primary objective of the study is to evaluate the safety of single doses of oral naldemedine in adults physically dependent on opioids.

Completed7 enrollment criteria

Opioid-induced Bowel Dysfunction: Long-Term Assessment of Lubiprostone

Opioid-Induced Bowel Dysfunction

The purpose of this study is to evaluate the long-term safety and efficacy of lubiprostone administration in participants with opioid-induced bowel dysfunction.

Completed6 enrollment criteria

Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients...

Opioid-Induced Constipation

This study will evaluate the safety and efficacy of methylnaltrexone administered as subcutaneous injections in subjects who have opioid-induced constipation and an advanced illness. The hypothesis is that methylnaltrexone will be safe and effective in relieving opioid-induced constipation in these subjects.

Completed10 enrollment criteria
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