Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens
Heroin DependenceOpioid-Related DisordersHeroin dependence remains a major addiction problem in the United States. The purpose of this study is to determine the effectiveness of levoacetyl methadol (ORLAAM) in treating heroin dependent individuals.
Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia
HyperalgesiaOpioid-Related DisordersIndividuals who reduce or stop use of opioid medications are at risk for developing hyperalgesia, which is an increased sensitivity to pain. This study will compare the effectiveness of dextromethorphan, gabapentin, and oxycodone at reducing hyperalgesia in individuals addicted to opioids who are concurrently receiving methadone treatment.
Comparison of HIV Clinic-based Treatment With Buprenorphine Versus Referred Care in Heroin-dependent...
Opiate DependenceHIV Seropositivity1 moreThe purpose of this study is to compare the effectiveness of two approaches to treating HIV-infected patients who are addicted to opioid drugs (e.g., heroin) in an inner-city HIV clinic. The two approaches are: Case management and referral - participants are managed by a case manager and referred to a specialized drug treatment center where they receive counseling and medications for opioid-dependence (e.g., methadone or buprenorphine); or Clinic-based treatment - participants receive counseling and treatment with buprenorphine at the HIV clinic.
Addition of Naltrexone to Methadone Taper
Heroin DependenceOpioid-Related Disorders1 moreThere is a continuing search for more effective opiate detoxification treatments. This study's purpose is to investigate the effects of adding very low doses of naltrexone to a methadone tapering treatment in opioid dependent individuals.
Buprenorphine Maintenance Protocol - 1
Opioid-Related DisordersThe purpose of this study is to compare the efficacy of buprenorphine versus methadone.
Buprenorphine Maintenance Dose Schedule and Treatment Setting - 2
Opioid-Related DisordersSubstance-Related DisordersThe purpose of this study is to evaluate the efficacy of treating opioid-dependent individuals with buprenorphine on a thrice-weekly schedule compared to daily dosing.
Trial of Buprenorphine/Naloxone for Opiate Dependence - 2
Opioid-Related DisordersSubstance-Related DisordersThe purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate dependence treatment.
Alternate-Day Buprenorphine. Phase V - 6
Opioid-Related DisordersThe purpose of this study is to evaluate buprenorphine blockade challenge.
Alternate-Day Buprenorphine Administration. Phase VIII - 9
Opioid-Related DisordersThe purpose of this study is to evaluate open buprenorphine dosing with dose choice.
Effects of Dynorphin 1-13 on Heroin Addiction - 1
Opioid-Related DisordersSubstance Withdrawal SyndromeThe purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.