Safety Study of TissueGene-C in Degenerative Joint Disease of the Knee
OsteoarthritisKneeThe study is being conducted to investigate the safety and activity of TissueGene-C injected into the knee joint of patients with chronic degenerative joint disease (DJD) who will be undergoing total knee replacement.
A Study of GW842166 in Adults With Osteoarthritis Pain
OsteoarthritisKneeThe purpose of this study is to determine whether GW842166 is effective in the treatment of osteoarthritis pain of the knee.
Effects of Aquamin F on Osteoarthritis of the Knee
Osteoarthritis of the KneeThe objective of this trial is to evaluate the effect of Aquamin F alone or in combination with glucosamine sulfate versus placebo on symptoms of joint pain, stiffness and immobility in subjects with painful osteoarthritis of the knee. The following hypotheses were tested: (Hypothesis 1) After 12 weeks of treatment, subjects taking Aquamin F alone or in combination with glucosamine sulfate will have significantly less joint pain, stiffness and immobility compared to subjects taking glucosamine sulfate alone or placebo alone. (Hypothesis 2) No significant differences will be seen for adverse events between the subjects taking Aquamin F, glucosamine sulfate, Aquamin F + glucosamine sulfate or placebo.
Leeches for the Treatment of Knee Osteoarthritis
OsteoarthritisArthralgiaPrevious studies have not addressed the question, whether or not a repeated leeching can supply symptomatic relief of osteoarthritic pain for extended periods of time. We present a randomized study to the effectiveness of single and repeated leech therapy in cases with advanced osteoarthritis of the knee using a large patient group compared to a control group, who were both blinded to the actual treatment modality.
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)
OsteoarthritisThis 39-week, active controlled, study is designed to assess long-term efficacy, safety and tolerability of lumiracoxib 100mg od in patients with osteoarthritis (OA) of the knee who participated in the 13-week core CCOX189A2361 study.
Derris Scandens Benth Extract VS Naproxen in Knee OA
Knee OsteoarthritisDerris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.
Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee
Knee OsteoarthritisThis study will test efficacy and safety of AAE581 compared to placebo in limiting cartilage loss in patients with painful knee osteoarthritis which is confirmed by X-ray
An Effectiveness and Safety Study of IDEA-033 in Comparison to Oral Naproxen and Placebo for the...
OsteoarthritisKneeThe purpose of this study is to identify the dose(s) of IDEA-033 that will provide a meaningful effect for treating osteoarthritis of the knee.
Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee...
OsteoarthritisKneeOral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney abnormality. A topical NSAID may relieve pain and other symptoms of osteoarthritis of the knee, while minimizing the side effects common to oral NSAIDs. The purpose of this study is to determine the safety and effectiveness of a topical NSAID when used alone or when combined with an oral NSAID in the treatment of osteoarthritis of the knee.
The Effect of Weight Loss and Exercise on Knee Osteoarthritis
OsteoarthritisKneeThis study will evaluate whether a program of weight loss and exercise can help individuals with knee osteoarthritis (OA).