Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors,...
Childhood Burkitt LymphomaChildhood Central Nervous System Choriocarcinoma34 moreThis phase I trial is studying the side effects and best dose of vorinostat when given together with bortezomib in treating young patients with refractory or recurrent solid tumors, including CNS tumors and lymphoma. Vorinostat and bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors
Childhood Central Nervous System Germ Cell TumorChildhood Choroid Plexus Tumor23 morePhase I trial to study the safety of combining O6-benzylguanine with temozolomide in treating children who have recurrent or refractory brain tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. O6-benzylguanine may increase the effectiveness of temozolomide by making tumor cells more sensitive to the drug.
Role of Surgery in Management of Pineal Region Tumors in Children
Brain TumorThe aim of this observational study is to learn about the role of surgery with its different approaches and modalities in the management of pineal region tumors in pediatric population.the main question it aims to answer is : How can surgery affect the outcome in children with pineal region tumors ?
Melatonin Replacement Therapy in Pinealectomized Patients
Pineal TumorThis is an open-label, single-arm, single-center, proof-of-concept study to assess the effects of melatonin on cardiac autonomic activity in melatonin non-proficient pinealectomized patients.
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients...
Central Nervous System NeoplasmPineoblastoma4 moreThis randomized phase II trial studies how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or central nervous system (CNS) primitive neuroectodermal tumors. Drugs used in chemotherapy, such as temozolomide and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether temozolomide and irinotecan hydrochloride are more effective with or without bevacizumab in treating medulloblastoma or CNS primitive neuroectodermal tumors.
Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors
Childhood Atypical Teratoid/Rhabdoid TumorChildhood Central Nervous System Germ Cell Tumor24 moreThis phase I trial is studying the side effects and best dose of lenalidomide in treating young patients with recurrent, progressive, or refractory CNS tumors. Lenalidomide may stop the growth of CNS tumors by blocking blood flow to the tumor. It may also stimulate the immune system in different ways and stop tumor cells from growing.
Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who...
Adult Anaplastic AstrocytomaAdult Anaplastic Ependymoma25 moreThis phase I trial is studying the side effects of fluorine F18 EF5 when given during positron emission tomography to find oxygen in tumor cells of patients who are undergoing surgery or biopsy for newly diagnosed brain tumors. Diagnostic procedures using fluorine F 18 EF5 and positron emission tomography to detect tumor hypoxia may help in planning cancer treatment
Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for...
Brain and Central Nervous System TumorsLong-term Effects Secondary to Cancer Therapy in ChildrenRATIONALE: Specialized radiation therapy that delivers radiation directly to the area where a tumor was surgically removed may kill any remaining tumor cells and cause less damage to normal tissue. PURPOSE: This phase II trial is studying how well proton beam radiation therapy works in treating young patients who have undergone biopsy or surgery for medulloblastoma or pineoblastoma.
Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent...
PineoblastomaChildren, adolescents and young adults with relapsed or treatment refractory pineoblastoma (rPB) represent a group of patients with dismal prognosis for whom a recommended standard salvage therapy is currently not available.
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory...
Central Nervous System Embryonal Tumor With Rhabdoid FeaturesCentral Nervous System Embryonal Tumor15 moreThis phase I/II trial studies the side effects and best dose of adavosertib and irinotecan hydrochloride in treating younger patients with solid tumors that have come back (relapsed) or that have not responded to standard therapy (refractory). Adavosertib and irinotecan hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.