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Active clinical trials for "Pleural Effusion, Malignant"

Results 91-100 of 125

Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion

Lung CancerBreast Cancer1 more

This is a prospective, open-label , multicenter randomized controlled trial, with 248 cases in 50 centers planned for a period of 2 years. The aim of the study is to evaluate the safety and effectiveness of microparticles packaging chemotherapeutic drugs (MPCD) therapy on the treatment of malignant pleural effusion (MPE) in patients with advanced lung cancer or breast cancer.

Unknown status21 enrollment criteria

Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate...

Pleural EffusionMalignant

The primary goal of this study is to compare well-defined pleural effusion management success outcomes in patients with malignant or paramalignant pleural effusions who were treated with Indwelling pleural catheter insertion compared with those treated with siver nitrate pleurodesis. It is also to demonstrate the effectiveness of silver nitrate pleurodesis. It is also important to evaluate frequent adverse events of silver nitrate pleurodesis in patients with malignant pleural effusion

Unknown status11 enrollment criteria

Efficacy and Safety of Bevacizumab Versus Pulvis Talci in Malignant Pleural Effusion

Malignant Pleural Effusion

Patients with Malignant pleural effusion can be diagnosis advanced cancer. Currently recognized as the most reliable method to control malignant pleural effusion is pleural fixed or thoracic catheter drainage. The most effective pleural fixed agent is pulvis talci, but there are about 30% relapse rate. Thoracic drainage can lead to some complications, such as chest infections, catheter migration and blockage etc. The investigators need a reliable methods to solve dyspnea and other symptoms caused by malignant pleural effusion, and improve quality of life. The purpose of this study was to determine the efficacy and Safety of intrapleural Bevacizumab versus pulvis talci as treatment for malignant pleural effusions (MPE) in patients.

Unknown status10 enrollment criteria

Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis

Pleural EffusionMalignant1 more

Prospective study of the effect of Talc Pleurodesis vs. Indwelling Pleural catheter in treatment of patients with malignant pleural effusion

Unknown status18 enrollment criteria

A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC

Malignant Pleural EffusionNonsmall Cell Lung Cancer1 more

This randomized phase II study compare survival outcomes and toxicity of malignant pleural effusion stage IV non small-cell lung cancer patients Intrapleural infusion chemotherapy in combination with concurrent thoracic radiation therapy (TRT) VS not combination with concurrent thoracic radiation therapy (TRT).

Unknown status20 enrollment criteria

Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination...

Malignant Pleural Effusion

Title of study: Comparison of the Effectiveness of Povidone-Iodine alone to Povidone-Iodine--Tetracycline Combination for Chemical Pleurodesis in Malignant Pleural Effusion. Research design: Prospective Randomized Controlled Clinical Trial. Background: Malignant pleural effusion (MPE) is commonly encountered in clinical practice among patients with malignancy. In addition to its association with major morbidities, it also poses a high risk of recurrence following drainage. Chemical pleurodesis is often required to achieve pleural adhesion and obliteration of the pleural space to prevent such recurrence. Several agents are in common use for chemical pleurodesis with mixed effectiveness.

Unknown status9 enrollment criteria

Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients

Malignant Pleural Effusion

This study will take place in Ottawa, Ontario, and will include 100 patients who are receiving tunnelled pleural catheters to treat their symptoms of MPE. The aim of this study is to evaluate the effectiveness of the shorter versus longer external length Rocket® pleural catheter in managing malignant pleural effusions in terms of patients' self-rated quality of life, its ease of use, the incidence of complications, and levels of health care provider satisfaction.

Unknown status12 enrollment criteria

A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or...

Malignant Pleural EffusionMalignant Ascites

Malignant pleural effusion and/ or malignant ascites is generally defined by presence of malignant cells in the effusion fluid. The first-line therapies are mostly intrusive, medically demanding and inefficient, and therefore, it is important to study and develop new therapeutic option to address the unmet need. This protocol for BSG-001 is developed for the treatment of malignant pleural effusion and/ or malignant ascites. BSG-001 is an immune-modulator primarily exerts its effect via Toll-like receptor. The purpose of this study is to assess the safety and tolerability of BSG-001. All eligible subjects will receive BSG-001 for at least 12 weeks (3 cycles).

Unknown status15 enrollment criteria

Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung...

Malignant Pleural Effusion

The purpose of this study is to explore the efficacy and safety of different doses of bevacizumab injection in the treatment of malignant pleural effusion in patients with advanced non-squamous non-small cell lung cancer.

Unknown status38 enrollment criteria

Talc Outpatient Pleurodesis With Indwelling Catheter

Pleural EffusionPleural Diseases1 more

This study will be a prospective, randomized trial comparing a new protocol to the standard of care. The investigators protocol and the standard of care involves a previously established procedure that will be completed in the investigators pulmonary procedure unit. The study will include using previously, well-established procedures (indwelling pleural catheter placement, talc slurry administration through an indwelling pleural catheter, pleuroscopy with talc poudrage administration) in addition to a new protocol (at home continuous drainage via indwelling pleural catheter).

Unknown status12 enrollment criteria
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