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Active clinical trials for "Arthritis"

Results 911-920 of 3640

Crossover Study of Safety and Tolerability of Two Formulations of Adalimumab.

Rheumatoid Arthritis

This study will compare injection site pain levels between current Humira® formulation versus a new formulation of Humira in patients with Rheumatoid Arthritis (RA), who are either currently on a stable dose (minimum six consecutive doses) of on-label Humira or biological naïve who will be prescribed on-label Humira as treatment for their Rheumatoid Arthritis. The study is being conducted in two countries, Belgium (3 sites) and the Czech Republic (3 sites).

Completed10 enrollment criteria

A Study is to Assess Efficacy and Safety of Tacrolimus in Active Rheumatoid Arthritis Patients Who...

Rheumatoid Arthritis

This study is to assess efficacy and safety of tacrolimus in active rheumatoid arthritis patients who showed unsuccessful response to existing DMARDs.

Completed16 enrollment criteria

Low Dose Rituximab as a First Line Biologic Therapy for the Treatment of DMARD Resistant Patients...

DMARD Resistant Rheumatoid Arthritis

In this project the investigators decide to evaluate the efficacy and safety of half dose mabthera (it means 500 mg infusion two weeks apart) in conventional drug resistant cases of rheumatoid arthritis. The investigators choose this drug because the use of anti-TNF drugs limited in the investigators refractory patients as the first line drugs because of its cost.

Completed11 enrollment criteria

ALX-0061 Phase I Bioavailability Study in Healthy Volunteers

Rheumatoid Arthritis

The overall aims of the study are: To assess the bioavailability of single doses of ALX-0061, administered s.c. at three dose levels, using 2 corresponding single i.v. dose levels as reference. To provide additional information on pharmacokinetics and pharmacodynamics of ALX-0061. To further determine the safety and tolerability of ALX-0061. To further evaluate the systemic (serum) immunogenicity of ALX-0061.

Completed9 enrollment criteria

A Study of Golimumab in Participants With Active Psoriatic Arthritis

ArthritisPsoriatic

The purpose of this study is to evaluate the efficacy of intravenously (administration of a fluid into the vein) administered golimumab 2 milligram per kilogram (mg/kg) in participants with active psoriatic arthritis (a chronic inflammatory arthritis that is associated with psoriasis).

Completed8 enrollment criteria

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid...

Rheumatoid Arthritis

This is a first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single intravenous and subcutaneous doses of CFZ533 in healthy subjects and intravenous doses in rheumatoid arthritis patients.

Completed19 enrollment criteria

A Study to Investigate the Safety and Efficacy of ABT-122 Given With Methotrexate in Subjects With...

Rheumatoid Arthritis

This study is a Phase 2 randomized, double-blind, double-dummy, parallel-group study designed to assess the safety, tolerability, efficacy, pharmacokinetics and immunogenicity of multiple doses of ABT 122 in subjects with active rheumatoid arthritis (RA) who are inadequately responding to methotrexate (MTX) treatment.

Completed20 enrollment criteria

Study to Assess Safety and Efficacy of Anti-Interleukin 6-receptor (IL6R) Nanobody in Rheumatoid...

Rheumatoid Arthritis

The purpose of this study is to determine whether the ALX-0061, a Nanobody targeting the receptor for interleukin 6 (IL6R), is safe and effective after single or multiple administrations to patients with rheumatoid arthritis (RA). Patients will receive different single or multiple doses of either placebo or ALX-0061.

Completed21 enrollment criteria

A Prospective Study to Evaluate the Effectiveness of a Haemostatic Agent in Primary Unilateral Total...

Arthritis

This is a prospective, randomized, controlled, single-center study to assess the effectiveness of Vitagel, a surgical hemostat, in primary unilateral total hip arthroplasty (THA). This will be an inter-patient controlled study involving one-hundred-ten subjects. Vitagel will be used in a randomly selected cohort of fifty-five patients undergoing primary unilateral THA procedures; a control group of fifty-five patients will not receive Vitagel or any other hemostatic agent except those that are standard during a primary THA. The study will evaluate the effectiveness of Vitagel in reducing intra- and post-operative bleeding.

Completed21 enrollment criteria

Study of Subcutaneous Golimumab in Chinese Patients With Active Rheumatoid Arthritis Despite Methotrexate...

Rheumatoid Arthritis

The purpose of this study is to evaluate the safety and efficacy of golimumab in Chinese patients with rheumatoid arthritis.

Completed7 enrollment criteria
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